Identification of Core Gene Biomarkers in Patients with Diabetic Cardiomyopathy

Table 1

The top 5 upregulated and downregulated differentially expressed genes in patients with diabetic cardiomyopathy.

DEGs	Gene title	Gene symbol	LogFC	Biological function
Upregulated	Natriuretic peptide A	NPPA	3.53	Extracellular fluid volume and electrolyte homeostasis
	Secreted frizzled related protein 4	SFRP4	2.71	Soluble modulators of Wnt signaling
	Desmocollin 1	DSC1	2.44	Calcium-dependent glycoprotein
	Nebulin	NEB	2.4	Cytoskeleton
	Frizzled-related protein	FRZB	2.36	Soluble modulators of Wnt signaling
Downregulated	Serpin family E member 1	SERPINE1	−2.48	Inhibitor of fibrinolysis
	Serpin family A member 3	SERPINA3	−2.44	Anti-inflammatory and antioxidant effects
	Ankyrin repeat domain 2	ANKRD2	−2.16	Modulator of NF-κB-mediated inflammatory
	X-ray repair cross-complementing 4	XRCC4	−2.05	DNA repair
	S100 calcium-binding protein A8	S100A8	−1.98	Regulating inflammation and oxidative stress, activatingTLR4 signaling