Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters
Table 4
Association analysis of laboratory parameters and gene polymorphisms among SCA-HU+ and SCA-HU− patients.
(a)
Parameters
SCA-HU+ patients
MPO (GA + AA) N = 25
MPO (GG) N = 10
value
Total cholesterol (mg/dL)
115.8 ± 15.37
139.8 ± 29.98
0.004
LDL-C (mg/dL)
64.92 ± 16.96
84.31 ± 24.62
0.014
CYP2E1 (c1c2 + c2c2) N = 9
CYP2E1 (c1c1) N = 26
value
Alpha-1 antitrypsin (mg/dL)
137.16 ± 31.95
169.99 ± 40.92
0.037
Urea (mg/dL)
19.78 ± 5.99
15.85 ± 4.62
0.049
MCH (rg)
30.10 ± 2.99
33.38 ± 3.17
0.019
MCV (%)
88.12 ± 11.80
96.24 ± 8.72
0.036
GSTT1− N = 9
GSTT1+ N = 26
value
Total bilirubin (mg/dL)
2.62 ± 1.33
1.71 ± 0.71
0.043
Indirect bilirubin (mg/dL)
2.09 ± 1.38
1.25 ± 0.67
0.045∗∗
(b)
Parameters
SCA-HU− patients
MPO (GA + AA) N = 32
MPO (GG) N = 34
value
Globulin (g/dL)
3.74 ± 0.95
3.30 ± 0.78
0.043
Uric acid (mg/dL)
4.76 ± 1.55
3.67 ± 0.97
0.001
Glucose (mg/dL)
74.66 ± 6.60
70.21 ± 8.52
0.020
CYP2E1 (c1c2 + c2c2) N = 4
CYP2E1 (c1c1) N = 63
value
Monocytes (/mL)
685 ± 175
1020 ± 355
0.048
Ferritin (ng/dL)
57.18 ± 17.99
210.0 ± 176.4
0.002
Urea (mg/dL)
35.25 ± 29.67
16.67 ± 9.24
0.048
LDL-C: low-density lipoprotein cholesterol; MCH: mean corpuscular hemoglobin; MCV: mean corpuscular volume; MPO: myeloperoxidase; CYP2E1: cytochrome P450 2E1; GSTT1: glutathione S-transferase 1; SCA-HU+: SCA patient treated with HU; SCA-HU−: SCA patient untreated with HU. Unpaired t-test; Mann Whitney U test.
