Systematic Review and Meta-Analysis of Diagnostic Accuracy of miRNAs in Patients with Pancreatic Cancer

Table 2

Summary estimates of subgroup analysis for miRNA in pancreatic cancer diagnosis.

Subgroups	Number of studies	SEN (95% CI)	SPE (95% CI)	+LR (95% CI)	−LR (95% CI)	DOR (95% CI)	AUC (95% CI)
Source of patients
PDAC	46	0.81 (0.79, 0.83)	0.78 (0.76, 0.80)	3.19 (2.54, 4.02)	0.27 (0.21, 0.34)	14.35 (9.62, 21.40)	0.86 (0.82, 0.89)
PaC	63	0.81 (0.79, 0.82)	0.78 (0.76, 0.79)	3.42 (2.89, 4.05)	0.27 (0.23, 0.31)	14.98 (11.31, 19.84)	0.87 (0.84, 0.89)
Source of control
Healthy control	58	0.82 (0.81, 0.83)	0.76 (0.74, 0.78)	3.21 (2.66, 3.87)	0.26 (0.22, 0.31)	14.29 (10.41, 19.60)	0.86 (0.83, 0.88)
Disease control	51	0.79 (0.78, 0.81)	0.79 (0.78, 0.81)	3.46 (2.84, 4.23)	0.28 (0.23, 0.33)	14.96 (10.63, 21.05)	0.86 (0.83, 0.89)
Ethnicity
Asian	65	0.78 (0.77, 0.80)	0.76 (0.74, 0.78)	3.02 (2.55, 3.57)	0.30 (0.26, 0.34)	11.95 (9.05, 15.78)	0.84 (0.81, 0.86)
Caucasian	44	0.84 (0.82, 0.85)	0.80 (0.78, 0.82)	3.91 (3.10, 4.92)	0.23 (0.18, 0.29)	20.23 (13.61, 30.09)	0.88 (0.85, 0.91)
miRNA profiles
Single miRNA	71	0.75 (0.74, 0.77)	0.76 (0.74, 0.77)	2.82 (2.41, 3.29)	0.34 (0.30, 0.39)	9.48 (7.44, 12.08)	0.82 (0.79, 0.84)
Multiple miRNAs	38	0.87 (0.86, 0.88)	0.81 (0.79, 0.82)	4.65 (3.62, 5.97)	0.16 (0.13, 0.21)	35.88 (22.92, 56.16)	0.92 (0.89, 0.94)
Source of miRNA
Blood	80	0.79 (0.78, 0.80)	0.78 (0.76, 0.79)	3.35 (2.92, 3.84)	0.29 (0.25, 0.33)	13.64 (10.74, 17.33)	0.85 (0.83, 0.87)
Tissue	13	0.90 (0.88, 0.92)	0.90 (0.87, 0.92)	7.14 (4.43, 11.50)	0.09 (0.05, 0.19)	96.13 (39.20, 235.77)	0.96 (0.93, 0.98)
Fecal	13	0.80 (0.76, 0.84)	0.57 (0.49, 0.63)	1.77 (1.28, 2.44)	0.35 (0.23, 0.55)	5.52 (2.67, 11.42)	0.75 (0.66, 0.85)
Pancreatic juice	3	0.79 (0.68, 0.88)	0.60 (0.45, 0.74)	1.87 (1.31, 2.68)	0.34 (0.21, 0.57)	5.77 (2.53, 13.15)	0.76 (0.66, 0.85)
miRNA-21
Yes	24	0.85 (0.83, 0.87)	0.83 (0.80, 0.86)	4.76 (2.96, 7.66)	0.19 (0.13, 0.28)	30.24 (15.44, 59.21)	0.91 (0.87, 0.95)
No	85	0.80 (0.78, 0.81)	0.77 (0.75, 0.78)	3.06 (2.67, 3.50)	0.29 (0.25, 0.33)	12.31 (9.69, 15.65)	0.84 (0.82, 0.86)
Overall	109	0.81 (0.80, 0.82)	0.78 (0.77, 0.79)	3.32 (2.90, 3.80)	0.27 (0.24, 0.31)	14.56 (11.55, 18.34)	0.86 (0.84, 0.88)

SEN: sensitivity; SPE: specificity; +LR: positive likelihood ratio; −LR: negative likelihood ratio; DOR: diagnostic odds ratio; AUC: area under the curve; PDAC: pancreatic ductal adenocarcinoma.