Prognostic Factors and Survival in Primary Central Nervous System Lymphoma: A Population-Based Study
Table 1
Summary of characteristics for the patient population. SEER 1973–2014 ()a.
Characteristic
All patients number (%) ()
Immunocompromised patients number (%) ()
Immunocompetent patients number (%) ()
Age
<60
2735 (46.3)
737 (96.3)
1998 (38.9)
≥60
3168 (53.7)
28 (3.7)
3140 (61.1)
Sex
Male
3353 (56.8)
680 (88.9)
2673 (52.0)
Female
2550 (43.2)
85 (11.1)
2465 (48.0)
Race
Black
523 (8.9)
216 (28.3)
307 (6.0)
White
4816 (81.5)
525 (68.6)
4291 (83.5)
Other (American Indian/AK native, Asian/Pacific Islander)
564 (9.6)
24 (3.1)
540 (10.5)
Dates of diagnosis
1973–1984
188 (3.2)
5 (0.7)
183 (3.6)
1985–1995
1030 (17.4)
386 (50.5)
644 (12.5)
1996–2006
2265 (38.4)
250 (32.7)
2015 (39.2)
2007–2014
2420 (41.0)
124 (16.1)
2296 (44.7)
Lymphoma subtypes
DLBCL
4342 (73.6)
527 (68.9)
3815 (74.3)
Non-DLBCL
1561 (26.4)
238 (31.1)
1323 (25.7)
Primary site
Brain
4768 (80.8)
684 (89.4)
4084 (79.5)
Meninges/cranial nerves
110 (1.9)
7 (0.9)
107 (2.0)
Spine
364 (6.1)
18 (2.4)
346 (6.7)
Other
661 (11.2)
56 (7.3)
605 (11.8)
Laterality
Not a paired site
4197 (71.7)
662 (86.5)
3535 (68.8)
Paired site (left/right—origin of primary)
1706 (28.9)
103 (13.5)
1603 (31.2)
Lymphoma Ann Arbor stage
I–II
4324 (73.3)
585 (76.5)
3739 (72.8)
III–IV
116 (19.6)
147 (19.2)
1015 (19.8)
Unknown
417 (7.1)
33 (4.3)
384 (7.5)
Radiation
No
3015 (51.1)
289 (37.8)
2726 (53.1)
Yes
2785 (47.2)
465 (60.8)
2320 (45.2)
Unknown
103 (1.7)
11 (1.4)
92 (1.8)
Chemotherapy
Yes
3325 (56.3)
147 (19.2)
3178 (61.9)
No
2578 (43.7)
618 (80.8)
1960 (38.1)
Immunological status
Immunocompromised
765 (13.0)
—
—
Immunocompetent
5138 (87.0)
Vital status
Dead
4382 (74.2)
765 (100.0)
3617 (70.4)
Alive
1521 (25.8)
0 (0.0)
1521 (29.6)
Insurance status
Uninsured
101 (1.7)
12 (1.6)
89 (1.7)
Insured/any Medicaid
2271 (38.5)
107 (14.0)
2164 (42.1)
Insurance status unknown
3531 (59.8)
646 (84.4)
2885 (56.2)
Marital status
Never married
1409 (23.9)
566 (74.0)
843 (16.4)
Married
3170 (53.7)
107 (14.0)
3063 (59.6)
Ever married (divorced, separated, and widowed)
1142 (19.3)
63 (8.2)
1079 (21.0)
Unknown
182 (3.1)
9 (3.8)
153 (3.0)
Multiple modalities
Neither but conservative treatment
1104 (18.7)
233 (30.5)
871 (17.0)
Chemotherapy involving
3270 (55.4)
144 (18.8)
3126 (60.8)
Only radiation
1426 (24.2)
377 (49.3)
1049 (20.4)
Missing
103 (1.7)
11 (1.4)
92 (1.8)
SEER: Surveillance, Epidemiology, and End Results; DLBCL: diffuse large B cell lymphoma; PCNSL: primary central nervous system lymphoma. aData are presented as the number (percentage) of patients.
