Prognostic Factors and Survival in Primary Central Nervous System Lymphoma: A Population-Based Study

Table 2

Univariate and multivariate survival analysis in immunocompromised patients with DLBCL.

Variable	Univariate analysis		Multivariate analysis
	HR (95% CI)		HR (95% CI)
Age (years)
<60	Reference
≥60	0.727 (0.453–1.166)	0.186
Race
White	Reference
Black	1.194 (0.988–1.443)	0.067
Other (American Indian/AK native, Asian/Pacific Islander)	0.921 (0.573–1.480)	0.734
Gender
Female	Reference
Male	1.185 (0.908–1.546)	0.212
Dates of diagnosis
1973–1984	Reference		Reference
1985–1995	3.253 (1.027–10.304)	0.045	2.701 (0.472–15.466)	0.264
1996–2006	2.270 (0.718–7.179)	0.163	1.881 (0.329–10.747)	0.477
2007–2014	2.740 (0.858–8.756)	0.089	2.376 (0.411–13.728)	0.334
Primary site
Brain	Reference		Reference
Meninges/cranial nerves	0.313 (0.076–1.287)	0.107	0.603 (0.073–5.004)	0.640
Spine	0.465 (0.254–0.852)	0.013	0.487 (0.262–0.906)	0.023
Other	0.593 (0.709–1.541)	0.824	1.052 (0.692–1.600)	0.811
Laterality
Not a paired site	Reference
Paired site (left/right—origin of primary)	0.901 (0.709–1.145)	0.393
Lymphoma Ann Arbor stage
I–II	Reference		Reference
III–IV	1.452 (1.157–1.824)	0.001	1.499 (1.187–1.892)	0.001
Unknown	1.269 (0.833–1.935)	0.267	1.177 (0.735–1.886)	0.497
Radiation
No	Reference		Reference	<0.001
Yes	0.673 (0.562–0.806)	<0.001 0.569	0.662 (0.548–0.800)	0.925
Unknown	0.823 (0.422–1.607)		0.968 (0.490–1.914)
Chemotherapy
No	Reference		Reference
Yes	0.585 (0.465–0.735)	<0.001	0.554 (0.434–0.709)	<0.001
Insurance status
Uninsured	Reference
Insured/any Medicaid	0.708 (0.378–1.328)	0.282
Insurance status unknown	0.735 (0.403–1.339)	0.315
Marital status
Never married	Reference
Married	0.847 (0.660–1.087)	0.192
Ever married (divorced, separated, and widowed)	0.877 (0.647–1.189)	0.399
Unknown	1.097 (0.731–1.646)	0.654

OS: overall survival; HR: hazard ratio; CI: confidence interval; SEER: Surveillance, Epidemiology, and End Results; DLBCL: diffuse large B cell lymphoma; PCNSL: primary central nervous system lymphoma.