High Circulating Caspase-Cleaved Keratin 18 Fragments (M30) Indicate Short-Term Mortality in Critically Ill Patients
Table 3
Correlations of clinical scores and laboratory parameters with M30 serum concentrations at admission day (Spearman rank correlation test, only significant results are shown).
Parameters
ICU patients
Disease severity
APACHE II score
0.311
<0.001
SOFA score
0.390
<0.001
SAPS2 score
0.290
0.018
Inflammation
Procalcitonin
0.362
<0.001
suPAR
0.557
<0.001
Interleukin-6
0.163
0.023
TNF
0.441
0.002
Interleukin-10
0.369
<0.001
LDH
0.299
<0.001
Renal function
Creatinine
0.235
<0.001
GFR (creatinine)
−0.224
0.003
Cystatin C
0.292
<0.001
GFR (cystatin C)
−0.285
<0.001
Urea
0.192
0.003
Uric acid
0.158
0.027
Liver function
Protein
−0.269
<0.001
Albumin
−0.212
0.015
Pseudocholinesterase
−0.275
<0.001
Bilirubin
0.334
<0.001
Bilirubin (conjugated)
0.515
<0.001
Gamma GT
0.337
<0.001
Alkaline phosphatase
0.300
<0.001
AST
0.427
<0.001
ALT
0.358
<0.001
GLDH
0.466
<0.001
INR
0.402
<0.001
Prothrombin time
−0.391
<0.001
aPTT
0.389
<0.001
D-dimers
0.498
<0.001
Antithrombin III
−0.420
<0.001
Platelets
−0.185
0.004
Nonsignificant correlations were noted for M30 levels with blood count, sodium, potassium, magnesium, amylase, lipase, creatine kinase, C-reactive protein, thyroid stimulating hormone, vitamin D, parameters of mechanical ventilation, and central venous pressure.
