Genetic Polymorphisms Associated with Environmental Exposure to Polycyclic Derivatives in African Children
Table 4
Association of hematological parameters with variant allele of polymorphisms in GSTT1 and GSTM1 in both leukopenic and control children.
Hematological parameters
GSTT1 null
GSTM1 null
Leukopenic (4)
Controls (15)
Leukopenic (11)
Controls (20)
Mean ± SD
Mean ± SD
Mean ± SD
Mean ± SD
RBC (×106/mL)
4.53 ± 0.13
4.79 ± 0.08
0.1410
4.70 ± 0.09
4.65 ± 0.08
0.7101
Hemoglobin (g/dL)
12.88 ± 0.43
13.12 ± 0.20
0.5956
13.20 ± 0.14
12.83 ± 0.18
0.1791
Hematocrit (%)
38.38 ± 1.16
39.08 ± 0.61
0.6032
39.53 ± 0.48
38.21 ± 0.54
0.1152
RDW (%)
14.30 ± 0.77
15.25 ± 0.24
0.1337
14.75 ± 0.33
14.75 ± 0.19
0.9898
WBC (×103/mL)
3.70 ± 0.12
7.42 ± 0.52
0.0021
3.69 ± 0.06
7.11 ± 0.39
<0.0001
Neutrophils (×103/mL)
1.17 ± 0.07
3.22 ± 0.34
0.0081
1.27 ± 0.09
3.34 ± 0.33
<0.0001
Eosinophils (×103/mL)
0.23 ± 0.08
0.64 ± 0.14
0.1556
0.21 ± 0.04
0.42 ± 0.08
0.0618
Basophils (×103/mL)
0.03 ± 0.01
0.10 ± 0.008
0.0027
0.05 ± 0.01
0.08 ± 0.007
0.0449
Lymphocytes (×103/mL)
1.90 ± 0.09
2.93 ± 0.19
0.0142
1.84 ± 0.09
2.79 ± 0.14
<0.0001
Monocytes (×103/mL)
0.37 ± 0.06
0.52 ± 0.05
0.1789
0.33 ± 0.02
0.48 ± 0.03
0.0014
Platelets (×103/mL)
264.75 ± 18.75
279.67 ± 13.98
0.6141
287.45 ± 16.97
271.27 ± 12.10
0.5175
Uric acid (mg/dL)
4.45 ± 0.99
4.02 ± 0.65
0.5139
4.39 ± 0.91
4.25 ± 0.84
0.7525
Total cholesterol (mg/dL)
152.30 ± 42.53
172.10 ± 31.22
0.9801
180.40 ± 43.91
164.80 ± 34.72
0.0967
HDL-c (mg/dL)
39.25 ± 7.14
43.60 ± 6.30
0.2131
41.09 ± 10.35
44.30 ± 9.75
0.4323
LDL-c (mg/dL)
101.10 ± 37.82
114.90 ± 31.31
0.8989
119.20 ± 34.15
106.20 ± 29.32
0.1202
Triglycerides (mg/dL)
59.75 ± 19.52
68.33 ± 22.67
0.7500
100.40 ± 52.68
71.45 ± 37.12
0.0927
Creatinine (mg/dL)
0.65 ± 0.22
0.65 ± 0.16
0.9900
0.79 ± 0.35
0.61 ± 0.16
0.1790
Free iron (mg/dL)
88.75 ± 41.77
71.07 ± 22.19
0.3965
85.45 ± 41.90
86.20 ± 33.66
0.7069
Glucose (mg/dL)
93.25 ± 10.28
96.27 ± 6.47
0.5175
90.73 ± 9.56
97.50 ± 8.49
0.0882
Urea (mg/dL)
22.75 ± 4.11
24.47 ± 6.59
0.6068
24.73 ± 8.41
22.35 ± 4.52
0.7516
SD: standard deviation; RBC: red blood cell; RDW: red cell distribution width; WBC: white blood cell; HDL-c: high-density lipoproteins of cholesterol; LDL-c: low-density lipoproteins of cholesterol.
