Targeting mTOR in Glioblastoma: Rationale and Preclinical/Clinical Evidence

Figure 2

(a) mTORC2 protein composition; (b) mTORC2 upstream activators; (c) mTORC2 downstream targets; (d) mTORC2 cellular functions. Legend: mTOR: mechanistic target of rapamycin; RICTOR: rapamycin-insensitive companion of mTOR; mLST8: mammalian lethal with Sec-13 protein 8; DEPTOR: DEP domain TOR-binding protein; PROTOR: protein observed with RICTOR; mSIN1: stress-activated map kinase-interacting protein 1; PI3K: phosphatidylinositol-3-kinase; PIP2: phosphatidylinositol (4,5)-bisphosphate; PIP3: phosphatidylinositol (3,4,5)-trisphosphate; PTEN: phosphatase and tensin homolog; AKT: protein kinase B; SGK1: serum and glucocorticoid-regulated kinase 1; PKC: protein kinase C; HDACs: histone deacetylases; PFK-1: phosphofruttokinase-1; HK2: hexokinase 2; GLUT4: glucose transporter type 4; NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells.

(a)

(b)

(c)

(d)