ADAMTSL4, a Secreted Glycoprotein, Is a Novel Immune-Related Biomarker for Primary Glioblastoma Multiforme

Table 2

Uni- and multivariate Cox regression analysis of the risk score and clinical information for OS in CGGA.

Variable	Univariate Cox			Multivariate Cox
	value	HR	95% CI for HR	value	HR	95% CI for HR
Age
≥45 vs. <45	0.3486	1.2638	0.7746-2.0618
Gender
Male vs. female	0.2991	1.3016	0.7915-2.1404
IDH1/2 status
Mutation vs. wild-type	0.0465	0.4678	0.2214-0.9884	0.6466	0.7800	0.2697-2.2561
MGMT promoter status
Methylated vs. unmethylated	0.0479	0.6062	0.3692-0.9954	0.0609	0.4085	0.2407-1.0325
Radiotherapy
Yes vs. no	0.3621	0.7629	0.4263-1.3654
Chemotherapy
Yes vs. no	0.0440	0.5788	0.3400-0.9854	0.0976	0.5818	0.3065-1.1042
KPS score
Increasing score	0.0057	0.9733	0.9548-0.9922	0.0020	0.9663	0.9456-0.9876
ADAMTSL4 expression
Increasing expression	0.0061	1.2891	1.0753-1.5454	0.0289	1.3224	1.0293-1.6990

HR = hazard ratio; IDH1/2 = isocitrate dehydrogenase 1; MGMT = methylguanine methyltransferase; KPS = Karnofsky performance score. Factors with prognostic significance in univariate Cox regression analysis were included in further multivariate Cox analysis. Significant.