Research Article
ADAMTSL4, a Secreted Glycoprotein, Is a Novel Immune-Related Biomarker for Primary Glioblastoma Multiforme
Table 2
Uni- and multivariate Cox regression analysis of the risk score and clinical information for OS in CGGA.
| Variable | Univariate Cox | Multivariate Cox | value | HR | 95% CI for HR | value | HR | 95% CI for HR |
| Age | ≥45 vs. <45 | 0.3486 | 1.2638 | 0.7746-2.0618 | | | | Gender | Male vs. female | 0.2991 | 1.3016 | 0.7915-2.1404 | | | | IDH1/2 status | Mutation vs. wild-type | 0.0465 | 0.4678 | 0.2214-0.9884 | 0.6466 | 0.7800 | 0.2697-2.2561 | MGMT promoter status | Methylated vs. unmethylated | 0.0479 | 0.6062 | 0.3692-0.9954 | 0.0609 | 0.4085 | 0.2407-1.0325 | Radiotherapy | Yes vs. no | 0.3621 | 0.7629 | 0.4263-1.3654 | | | | Chemotherapy | Yes vs. no | 0.0440 | 0.5788 | 0.3400-0.9854 | 0.0976 | 0.5818 | 0.3065-1.1042 | KPS score | Increasing score | 0.0057 | 0.9733 | 0.9548-0.9922 | 0.0020 | 0.9663 | 0.9456-0.9876 | ADAMTSL4 expression | Increasing expression | 0.0061 | 1.2891 | 1.0753-1.5454 | 0.0289 | 1.3224 | 1.0293-1.6990 |
|
|
HR = hazard ratio; IDH1/2 = isocitrate dehydrogenase 1; MGMT = methylguanine methyltransferase; KPS = Karnofsky performance score. Factors with prognostic significance in univariate Cox regression analysis were included in further multivariate Cox analysis. Significant. |