Circular RNAs Hsa_circ_0002715 and Hsa_circ_0035197 in Peripheral Blood Are Novel Potential Biomarkers for New-Onset Rheumatoid Arthritis

Table 3

AUC for 4 circRNAs in discriminating new-onset RA patients from HC, AS patients, SLE patients, and UA patients.

Variables	AUC	value	95% C.I.	Sensitivity	Specificity	Cut-off
RA vs. HC
Hsa_circ_0035197	0.742	<0.0001	0.637-0.848	71.2%	68.6%	>1.454
Hsa_circ_0000367	0.713	0.0006	0.608-0.818	54.2%	82.9%	>2.121
Hsa_circ_0001947	0.709	0.0007	0.604-0.815	50.9%	88.6%	>1.847
Hsa_circ_0002715	0.686	0.0027	0.676-0.796	57.6%	77.1%	>1.847
RA vs. AS
Hsa_circ_0001947	0.793	<0.0001	0.700-0.886	62.71%	96.0%	>1.578
Hsa_circ_0035197	0.779	<0.0001	0.679-0.878	76.3%	84.0%	>1.315
Hsa_circ_0002715	0.715	0.0019	0.607-0.823	62.7%	84.0%	>1.717
Hsa_circ_0000367	0.673	0.0125	0.560-0.786	49.2%	96.0%	>2.594
RA vs. SLE
Hsa_circ_0000367	0.669	0.0028	0.566-0.771	52.5%	75.0%	>2.305
Hsa_circ_0035197	0.667	0.0031	0.561-0.773	100.0%	31.3%	>0.678
Hsa_circ_0001947	0.654	0.0063	0.551-0.757	52.5%	75.0%	>1.831
Hsa_circ_0002715	0.629	0.0219	0.522-0.736	86.4%	37.5%	<5.799
RA vs. UA
Hsa_circ_0001947	0.947	<0.001	0.901-0.992	83.1%	100.0%	>1.014
Hsa_circ_0035197	0.781	0.0002	0.654-0.909	78.0%	73.7%	>1.244
Hsa_circ_0002715	—	—	—	—	—	—
Hsa_circ_0000367	—	—	—	—	—	—

Ankylosing spondylitis (AS); area under the curve (AUC); circular RNAs (circRNAs); healthy controls (HC); rheumatoid arthritis (RA); receiver operating characteristic (ROC); systemic lupus erythematosus (SLE); undiagnosed arthritis (UA).