Identification of miRNA-Based Signature as a Novel Potential Prognostic Biomarker in Patients with Breast Cancer

Figure 1

Construction of the OS/RFS miRNA signatures. Tuning parameter () selection crossvalidation error curve for OS/RFS-relevant miRNA. The vertical lines were drawn at the optimal values by the minimum criteria and the 1-SE criteria (a, d). The LASSO coefficient profiles of 17 overall survival-related miRNAs; the vertical line is drawn at the value chosen by 10-fold crossvalidation (b). The LASSO coefficient profiles of 13 recurrence-free survival-related miRNAs; the vertical line is drawn at the value chosen by 10-fold crossvalidation (e). Hazard ratio of the enrolled OS-related miRNAs (c) and enrolled RFS-related miRNAs (f). LASSO coefficient profiles of OS-relevant miRNAs associated with the prognosis of patients with breast cancer (a–c); LASSO coefficient profiles of RFS-relevant miRNAs associated with the prognosis of patients with breast cancer (d–f).

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