Exploring the Diagnostic Potential of Serum Golgi Protein 73 for Hepatic Necroinflammation and Fibrosis in Chronic HCV Infection with Different Stages of Liver Injuries
Table 2
Demographic and clinical characteristics of the two cohorts.
Parameters
Cohort A ()
Cohort B ()
value
Age (y, )
0.438
Gender (M/F)
56/75
57/63
0.450
BMI (kg/m2, )
<0.001
HCV genotype (1b/2a/unknown)
62/46/23
45/52/23
0.274
HCV RNA (+/−)
121/10
100/20
0.028
TBIL (μmol/L)
12.9 (9.5, 18.4)
15.3 (11.2, 19.1)
0.014
ALT (U/L)
43.0 (26.0, 81.0)
37.6 (29.4, 65.9)
0.684
AST (U/L)
48.0 (29.0, 69.0)
35.4 (28.1, 47.7)
0.024
GGT (U/L)
34.0 (18.0, 66.0)
15.4 (12.3, 25.1)
<0.001
ALB (g/L, )
<0.001
GLB (g/L)
31.0 (27.0, 35.0)
27.2 (25.0, 30.4)
<0.001
PA (mg/L, )
0.392
RBC (1012/L, )
<0.001
PLT (109/L, )
0.011
PT (s)
11.3 (10.6, 12.1)
11.5 (11.0, 11.9)
0.003
GP73 (ng/mL, )
0.573
Necroinflammation activity grade (G: 0-1/2/3/4)
50/48/7/-
17/67/34/2
<0.001
Fibrosis stage (F: 0-1/2/3/4)
35/30/31/35
56/50/12/2
<0.001
Continuous variables were expressed as (SD) or median and interquartile range (IQR). BMI: body mass index; HCV: hepatitis C virus; TBIL: total bilirubin; ALT: alanine aminotransferase; AST: aspartate aminotransferase; GGT: gamma glutamyltransferase; ALB: albumin; GLB: globulin; PA: prealbumin; RBC: red blood cell; PLT: platelet; PT: prothrombin time; GP73: Golgi protein 73.
