Determination of SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, and RAGE rs1800625 Single Gene Polymorphisms in Patients with Laryngeal Squamous Cell Carcinoma

Table 3

Frequency of the genotypes of rs12778366, rs2981582, rs744166, and rs1800625 polymorphisms in the LSCC and in the control groups.

Gene marker	Genotype/allele	Control; (%); ()	LSCC; (%); ()	value
SIRT1 rs12778366	TT	645 (80.6)	106 (73.6)	0.111
	TC	141 (17.6)	36 (25.0)
	CC	14 (1.8)	2 (1.4)
	T	1431 (89.4)	248 (86.1)	0.098
	C	169 (10.6)	40 (13.9)
FGFR2 rs2981582	GG	337 (42.1)	63 (43.8)	0.886
	GA	351 (43.9)	60 (41.7)
	AA	112 (14.0)	21 (14.6)
	G	1025 (64.1)	186 (64.6)	0.865
	A	575 (35.9)	102 (35.4)
STAT3 rs744166	AA	283 (35.4)	47 (32.6)	0.818
	AG	363 (45.4)	68 (47.2)
	GG	154 (19.2)	29 (20.1)
	A	929 (58.1)	162 (56.3)	0.566
	G	671 (41.9)	126 (43.7)
RAGE rs1800625	AA	580 (72.5)	88 (61.1)	<0.001
	AG	206 (25.8)	44 (30.6)
	GG	14 (1.8)	12 (8.3)
	A	1366 (85.4)	220 (76.4)	<0.001
	G	234 (14.6)	68 (23.6)

HWE: Hardy-Weinberg equilibrium; SIRT1: sirtuin 1 gene; FGFR2: fibroblast growth factor receptor 2 gene; STAT3: signal transducer and activator of transcription 3 gene; RAGE: advanced glycosylation end product receptor gene; LSCC: laryngeal squamous cell carcinoma. values indicated in bold are statistically significant.