Determination of SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, and RAGE rs1800625 Single Gene Polymorphisms in Patients with Laryngeal Squamous Cell Carcinoma
Table 4
Binomial logistic regression analysis of rs12778366, rs2981582, rs744166, and rs1800625 polymorphisms in the laryngeal squamous cell carcinoma and in the control groups.
Model
Genotype
aOR (95% CI)
AIC
SIRT1 rs12778366
Codominant
T/C C/C
1.519 (0.951-2.426) 1.307 (0.241-7.095)
0.080 0.757
625.205
Dominant
T/C+C/C
1.506 (0.953-2.380)
0.080
623.235
Recessive
C/C
1.194 (0.221-6.461)
0.837
626.200
Overdominant
T/C
1.513 (0.948-2.413)
0.083
623.298
Additive
—
1.421 (0.937-2.155)
0.098
624.571
FGFR2 rs2981582
Codominant
G/A A/A
0.951 (0.624-1.452) 0.947 (0.525-1.705)
0.818 0.855
628.177
Dominant
G/A+A/A
0.950 (0.641-1.408)
0.799
626.177
Recessive
A/A
0.970 (0.559-1.683)
0.914
626.230
Overdominant
G/A
0.965 (0.650-1.433)
0.859
626.210
Additive
—
0.968 (0.734-1.276)
0.816
626.188
STAT3 rs744166
Codominant
A/G G/G
1.216 (0.783-1.887) 1.378 (0.790-2.404)
0.384 0.259
626.801
Dominant
A/G+G/G
1.260 (0.835-1.902)
0.271
625.015
Recessive
G/G
1.233 (0.752-2.023)
0.406
625.563
Overdominant
A/G
1.088 (0.736-1.608)
0.672
626.063
Additive
—
1.179 (0.898-1.548)
0.235
624.830
RAGE rs1800625
Codominant
A/G G/G
1.371 (0.887-2.120) 8.377 (2.880-24.368)
0.156 <0.001
611.143
Dominant
A/G+G/G
1.677 (1.112-2.529)
0.014
620.248
Recessive
G/G
7.623 (2.643-21.989)
<0.001
611.128
Overdominant
A/G
1.223 (0.796-1.877)
0.358
625.406
Additive
—
1.844 (1.301-2.613)
0.001
614.547
aOR: adjusted odds ratio by age and gender; CI: confidence interval; AIC: Akaike Information Criterion.
