Association of Single-Nucleotide Polymorphism REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 with Primary Lung Cancer Susceptibility: A Case-Control Study in a Chinese Population

Table 1

Demographic characteristics of the included patients and healthy control.

Variable	Case group (%)	Control group (%)	OR (95% CI)
Age
≤52	295 (26.3)	289 (25.8)	1.000
53-59	285 (25.4)	273 (24.4)	1.012 (0.802-1.278)
60-66	272 (24.3)	274 (24.4)	0.973 (0.770-1.228)
≥67	269 (24.0)	285 (25.4)	0.925 (0.733-1.167)
Gender
Male	797 (71.1)	797 (71.1)	1.000
Female	324 (28.9)	324 (28.9)	1.000 (0.833-1.200)
Degree of education
Primary school or below	564 (50.4)	418 (37.3)	1.000
Junior and senior high school	443 (39.6)	553 (49.3)	0.594 (0.497-0.709)
College degree or above	114 (10.2)	150 (13.4)	0.563 (0.428-0.741)
Marital status
Married	1054 (94.0)	1039 (92.7)	1.000
Others	64 (5.7)	66 (5.9)	0.956 (0.671-1.362)
Single	3 (0.3)	16 (1.4)	0.185 (0.054-0.636)
BMI (kg/m^2)
<18.5	124 (11.1)	51 (4.5)	1.000
18.5-23.9	694 (61.9)	613 (54.7)	0.466 (0.330-0.657)
≥24	303 (27.0)	457 (40.8)	0.273 (0.191-0.390)
Pollution near the place of residence
Not	900 (80.3)	1026 (91.5)	1.000
Exist	221 (19.7)	95 (8.5)	2.652 (2.052-3.428)
House type
Bungalow	377 (33.6)	182 (16.2)	1.000
Building	734 (65.5)	931 (83.1)	0.381 (0.311-0.466)
Others	10 (0.9)	8 (0.7)	0.603 (0.234-1.555)
Ventilation situation
Well	859 (76.6)	990 (88.3)	1.000
General	223 (19.9)	115 (10.3)	2.235 (1.753-2.849)
Worse	39 (3.5)	16 (1.4)	2.809 (1.559-5.063)
Cooking oil fume (COF)
No	190 (16.9)	350 (31.2)	1.000
Little	613 (54.7)	544 (48.5)	2.076 (1.681-2.563)
Some	269 (24.0)	205 (18.3)	2.417 (1.876-3.114)
Much	49 (4.4)	22 (2.0)	4.103 (2.407-6.992)
Kitchen ventilator
No	480 (42.8)	337 (30.1)	1.000
Yes	641 (57.2)	784 (69.9)	0.574 (0.482-0.683)
Decoration within 10 years
No	674 (60.1)	692 (61.7)	1.000
Yes	447 (39.9)	429 (38.3)	1.070 (0.903-1.268)
Smoking
No	425 (37.9)	659 (58.8)	1.000
Yes	696 (62.1)	462 (41.2)	2.336 (1.972-2.767)
Passive smoking
No	335 (29.9)	621 (55.4)	1.000
Yes	786 (70.1)	500 (44.6)	2.914 (2.449-3.467)
Drink alcohol
No	733 (65.4)	805 (71.8)	1.000
Yes	388 (34.6)	316 (28.2)	1.348 (1.127-1.613)
Drink tea
No	566 (50.5)	537 (47.9)	1.000
Yes	555 (49.5)	584 (52.1)	0.902 (0.764-1.064)
History of lung disease
No	983 (87.7)	1025 (91.4)	1.000
Yes	138 (12.3)	96 (8.6)	1.499 (1.139-1.973)
Family history of cancer
No	900 (80.3)	950 (84.7)	1.000
Yes	221 (19.7)	171 (15.3)	1.364 (1.095-1.699)

BMI = weight (kg)/height² (m²).