Association of Single-Nucleotide Polymorphism REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 with Primary Lung Cancer Susceptibility: A Case-Control Study in a Chinese Population
Table 3
Association of another three SNPs with susceptibility to lung cancer.
Classification
Case (%)
Control (%)
OR (95% CI)
aOR (95% CI)#
rs6815391
Codominant
TT
477 (46.8)
472 (45.7)
1.000
1.000
CT
438 (42.9)
435 (42.1)
0.996 (0.829-1.197)
0.901 (0.732-1.109)
CC
105 (10.3)
126 (12.2)
0.825 (0.618-1.100)
0.925 (0.670-1.279)
Dominant
TT
477 (46.8)
472 (45.7)
1.000
1.000
CT+CC
543 (53.2)
561 (54.3)
0.958 (0.805-1.139)
0.906 (0.745-1.102)
Recessive
TT+CT
915 (89.7)
907 (87.8)
1.000
1.000
CC
105 (10.3)
126 (12.2)
0.826 (0.628-1.087)
0.973 (0.715-1.323)
Additive
0.936 (0.823-1.065)
0.942 (0.814-1.089)
rs3740535
Codominant
GG
602 (57.4)
614 (56.9)
1.000
1.000
AG
373 (35.6)
401 (37.1)
0.949 (0.792-1.136)
0.916 (0.747-1.124)
AA
73 (7.0)
64 (6.0)
1.163 (0.817-1.657)
1.067 (0.714-1.594)
Dominant
GG
602 (57.4)
614 (56.9)
1.000
1.000
AG+AA
446 (42.6)
465 (43.1)
0.978 (0.824-1.162)
0.937 (0.772-1.139)
Recessive
AG+GG
975 (93.0)
1015 (94.0)
1.000
1.000
AA
73 (7.0)
64 (6.0)
1.187 (0.839-1.680)
1.103 (0.744-1.636)
Additive
1.013 (0.882-1.163)
0.974 (0.833-1.139)
rs3130932
Codominant
TT
453 (43.4)
453 (41.8)
1.000
1.000
GT
460 (44.0)
494 (45.7)
0.931 (0.776-1.117)
0.890 (0.725-1.093)
GG
132 (12.6)
135 (12.5)
0.978 (0.744-1.285)
1.031 (0.757-1.404)
Dominant
TT
453 (43.4)
453 (41.8)
1.000
1.000
GT+GG
592 (56.6)
629 (58.2)
0.941 (0.793-1.118)
0.919 (0.757-1.116)
Recessive
GT+TT
913 (87.4)
947 (87.5)
1.000
1.000
GG
132 (12.6)
135 (12.5)
1.014 (0.785-1.311)
1.095 (0.819-1.463)
Additive
0.972 (0.857-1.101)
0.977 (0.848-1.125)
#By the degree of education, marital status, BMI, pollution near the place of residence, house type, ventilation situation, COF, kitchen ventilator, smoking, passive smoking, drink alcohol, history of lung disease, and family history of cancer adjusted.