Association of Single-Nucleotide Polymorphism REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 with Primary Lung Cancer Susceptibility: A Case-Control Study in a Chinese Population

Table 4

Association of the four SNPs of different pathological types with susceptibility to lung cancer.

	Lung adenocarcinoma		Lung squamous cell carcinoma		Total
Classification	Case/control	aOR (95% CI)^#	Case/control	aOR (95% CI)^#	Case/control	aOR (95% CI)^#
rs13409; Codominant
CC	252/466	1.000	147/466	1.000	490/466	1.000
CT	177/478	0.689 (0.536-0.885)	109/478	0.756 (0.543-1.053)	369/478	0.734 (0.610-0.884)
TT	58/109	0.987 (0.672-1.450)	30/109	0.754 (0.444-1.282)	113/109	0.986 (0.736-1.320)
rs13409; Dominant
CC	352/466	1.000	147/466	1.000	490/466	1.000
CT+TT	235/587	0.745 (0.589-0.941)	139/587	0.756 (0.553-1.033)	482/587	0.781 (0.656-0.930)
rs13409; Recessive
CC+CT	429/944	1.000	256/944	1.000	859/944	1.000
TT	58/109	1.171 (0.811-1.692)	30/109	0.861 (0.518-1.430)	859/109	1.039 (0.862-1.506)
rs13409; Additive		0.879 (0.737-1.048)		0.827 (0.653-1.047)		0.897 (0.788-1.022)
rs6815391; Codominant
TT	230/472	1.000	136/472	1.000	452/472	1.000
CT	205/435	0.905 (0.705-1.161)	125/435	1.028 (0.740-1.428)	418/435	1.003 (0.833-1.209)
CC	49/126	0.836 (0.562-1.241)	26/126	0.830 (0.482-1.429)	101/126	0.837 (0.625-1.121)
rs6815391; Dominant
TT	230/472	1.000	136/472	1.000	452/472	1.000
CT+CC	254/561	0.890 (0.703-1.126)	151/561	0.986 (0.722-1.348)	519/561	0.966 (0.810-1.152)
rs6815391; Recessive
TT+CT	435/907	1.000	261/907	1.000	870/907	1.000
CC	49/126	0.876 (0.600-1.278)	26/126	0.819 (0.488-1.377)	101/126	0.836 (0.633-1.103)
rs6815391; Additive		0.911 (0.764-1.086)		0.952 (0.752-1.204)		0.943 (0.828-1.074)
rs3740535; Codominant
GG	295/614	1.000	159/614	1.000	571/614	1.000
AG	169/401	0.875 (0.683-1.123)	114/401	1.034 (0.748-1.430)	354/401	0.949 (0.791-1.140)
AA	35/64	0.968 (0.598-1.567)	19/64	1.243 (0.650-2.375)	72/64	1.210 (0.848-1.726)
rs3740535; Dominant
GG	295/614	1.000	159/614	1.000	571/614	1.000
GA+AA	204/465	0.889 (0.702-1.126)	133/465	1.061 (0.778-1.447)	426/465	0.985 (0.828-1.172)
rs3740535; Recessive
GA+GG	464/1015	1.000	273/1015	1.000	925/1015	1.000
AA	35/64	1.018 (0.634-1.632)	19/64	1.226 (0.650-2.314)	72/64	1.234 (0.871-1.749)
rs3740535; Additive		0.930 (0.769-1.124)		1.073 (0.834-1.381)		1.024 (0.891-1.178)
rs3130932; Codominant
TT	228/453	1.000	119/453	1.000	432/453	1.000
GT	213/494	0.786 (0.613-1.008)	124/494	1.030 (0.737-1.440)	438/494	0.930 (0.773-1.118)
GG	57/135	0.893 (0.611-1.307)	46/135	1.593 (0.999-2.541)	125/135	0.971 (0.736-1.280)
rs3130932; Dominant
TT	228/453	1.000	119/453	1.000	432/453	1.000
GT+GG	270/629	0.807 (0.639-1.021)	170/629	1.146 (0.838-1.567)	563/629	0.939 (0.789-1.117)
rs3130932; Recessive
GT+TT	441/947	1.000	243/947	1.000	870/947	1.000
GG	57/135	1.009 (0.705-1.446)	46/135	1.569 (1.016-2.425)	125/135	1.008 (0.777-1.307)
rs3130932; Additive		0.894 (0.752-1.064)		1.201 (0.961-1.501)		0.969 (0.853-1.100)

^#By the degree of education, marital status, BMI, pollution near the place of residence, house type, ventilation situation, COF, kitchen ventilator, smoking, passive smoking, drink alcohol, history of lung disease, and family history of cancer adjusted. OR and its interval shown in italic font to represent the .