Association of Single-Nucleotide Polymorphism REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 with Primary Lung Cancer Susceptibility: A Case-Control Study in a Chinese Population
Table 6
Joint and multiplication interaction between gene recessive model and environmental factors.
Genotype
Environment
Case (%)
Control (%)
OR (95% CI)
aOR (95% CI)#
rs13409
rs13409 with pollution near the place of residence
CT+CC
No
736 (72.0)
866 (82.2)
1.000
1.000
CT+CC
Yes
165 (16.1)
78 (7.4)
2.489 (1.869-3.315)
2.224 (1.624-3.046)
TT
No
88 (8.6)
103 (9.8)
1.005 (0.744-1.358)
0.909 (0.649-1.272)
TT
Yes
33 (3.2)
6 (0.6)
6.471 (2.697-15.530)
6.308 (2.516-15.815)
rs13409 × pollution near the place of residence
ORmultiply (95% CI)
5.823 (2.429-13.956)
5.766 (2.302-14.444)
rs13409 with house type
CT+CC
No
303 (29.6)
156 (14.8)
1.000
1.000
CT+CC
Yes
598 (58.5)
788 (74.8)
0.402 (0.302-0.535)
0.448 (0.328-0.613)
TT
No
45 (4.4)
17 (1.6)
2.600 (1.046-6.463)
2.935 (1.131-7.617)
TT
Yes
76 (7.4)
92 (8.7)
0.404 (0.273-0.598)
0.401 (0.261-0.617)
rs13409 × house type
ORmultiply (95% CI)
1.009 (0.866-1.175)
0.846 (0.595-1.203)
rs13409 with ventilation situation
CT+CC
No
31 (3.0)
13 (1.2)
1.000
1.000
CT+CC
Yes
870 (85.1)
931 (88.4)
0.392 (0.204-0.754)
0.509 (0.248-1.045)
TT
No
5 (0.5)
2 (0.2)
1.048 (0.180-6.112)
1.311 (0.194-8.848)
TT
Yes
116 (11.4)
107 (10.2)
0.455 (0.226-0.914)
0.544 (0.252-1.175)
rs13409 × ventilation situation
ORmultiply (95% CI)
1.132 (0.857-1.495)
2.274 (1.095-4.724)
rs13409 with kitchen ventilator
CT+CC
No
381 (37.3)
275 (26.1)
1.000
1.000
CT+CC
Yes
520 (50.9)
669 (63.5)
0.561 (0.463-0.680)
0.913 (0.718-1.160)
TT
No
58 (5.7)
40 (3.8)
1.047 (0.680-1.612)
0.934 (0.577-1.512)
TT
Yes
63 (6.2)
69 (6.6)
0.659 (0.453-0.959)
1.046 (0.680-1.608)
rs13409 × kitchen ventilator
ORmultiply (95% CI)
0.937 (0.658-1.333)
1.117 (0.752-1.658)
rs13409 with COF
CT+CC
No
149 (14.6)
311 (29.5)
1.000
1.000
CT+CC
Yes
752 (73.6)
633 (60.1)
2.480 (1.986-3.096)
2.177 (1.696-2.794)
TT
No
23 (2.3)
24 (2.3)
2.000 (1.093-3.661)
2.403 (1.236-4.673)
TT
Yes
98 (9.6)
85 (8.1)
2.406 (1.696-3.415)
1.864 (1.260-2.759)
rs13409 × COF
ORmultiply (95% CI)
1.208 (0.891-1.637)
1.015 (0.916-1.124)
rs13409 with smoking
CT+CC
No
351 (34.3)
561 (53.3)
1.000
1.000
CT+CC
Yes
550 (53.8)
383 (36.4)
2.295 (1.905-2.766)
1.954 (1.559-2.450)
TT
No
40 (3.9)
64 (6.1)
0.999 (0.658-1.516)
0.935 (0.592-1.477)
TT
Yes
81 (7.9)
45 (4.3)
2.877 (1.952-4.241)
2.287 (1.468-3.563)
rs13409 × smoking
ORmultiply (95% CI)
1.928 (1.325-2.086)
1.515 (0.995-2.307)
rs13409 with passive smoking
CT+CC
No
271 (26.5)
528 (50.1)
1.000
1.000
CT+CC
Yes
630 (61.6)
416 (39.5)
2.951 (2.436-3.574)
2.403 (1.945-2.969)
TT
No
36 (3.5)
56 (5.3)
1.253 (0.804-1.925)
1.111 (0.683-1.807)
TT
Yes
85 (8.3)
53 (5.0)
3.125 (2.152-4.537)
2.445 (1.622-3.684)
rs13409 × passive smoking
ORmultiply (95% CI)
1.712 (1.201-2.440)
1.475 (0.997-2.181)
rs13409 with drink alcohol
CT+CC
No
598 (58.5)
675 (64.1)
1.000
1.000
CT+CC
Yes
303 (29.6)
269 (25.5)
1.271 (1.043-1.549)
0.829 (0.652-1.052)
TT
No
73 (7.1)
75 (7.1)
1.099 (0.782-1.544)
0.983 (0.669-1.444)
TT
Yes
48 (4.7)
34 (3.2)
1.594 (1.013-2.506)
0.992 (0.594-1.659)
rs13409 × drink alcohol
ORmultiply (95% CI)
1.477 (0.944-2.312)
1.070 (0.647-1.768)
rs13409 with history of lung disease
CT+CC
No
793 (77.6)
859 (81.6)
1.000
1.000
CT+CC
Yes
108 (10.6)
85 (8.1)
1.376 (1.019-1.858)
1.289 (0.915-1.816)
TT
No
101 (9.9)
105 (10.0)
1.042 (0.780-1.392)
0.944 (0.682-1.308)
TT
Yes
20 (2.0)
4 (0.4)
5.416 (1.843-15.914)
4.406 (1.394-13.930)
rs13409 × history of lung disease
ORmultiply (95% CI)
5.235 (1.783-15.368)
4.313 (1.366-13.620)
rs13409 with family history of cancer
CT+CC
No
714 (69.9)
805 (76.4)
1.000
1.000
CT+CC
Yes
187 (18.3)
139 (13.2)
1.517 (1.191-1.931)
1.522 (1.160-1.998)
TT
No
101 (9.9)
91 (8.6)
1.251 (0.926-1.690)
1.101 (0.784-1.546)
TT
Yes
20 (2.0)
18 (1.7)
1.253 (0.657-2.387)
1.296 (0.632-2.661)
rs13409 × family history of cancer
ORmultiply (95% CI)
1.148 (0.604-2.182)
1.197 (0.584-2.453)
rs6815391
rs6815391 with pollution near the place of residence
TT+CT
No
733 (71.9)
832 (80.5)
1.000
1.000
TT+CT
Yes
182 (17.8)
75 (7.3)
2.754 (2.068-3.669)
2.474 (1.812-3.377)
CC
No
88 (8.6)
115 (11.1)
0.869 (0.647-1.166)
1.001 (0.721-1.389)
CC
Yes
17 (1.7)
11 (1.1)
1.754 (0.816-3.769)
1.963 (0.855-4.505)
rs6815391 × pollution near the place of residence
ORmultiply (95% CI)
1.575 (0.734-3.379)
1.754 (0.764-4.026)
rs6815391 with house type
TT+CT
No
302 (29.6)
144 (13.9)
1.000
1.000
TT+CT
Yes
613 (60.1)
763 (73.9)
0.383 (0.306-0.480)
0.508 (0.391-0.661)
CC
No
32 (3.1)
21 (2.0)
0.727 (0.405-1.304)
0.844 (0.445-1.602)
CC
Yes
73 (7.2)
105 (10.2)
0.332 (0.232-0.474)
0.517 (0.344-0.777)
rs6815391 × house type
ORmultiply (95% CI)
0.681 (0.499-0.931)
0.875 (0.616-1.243)
rs6815391 with ventilation situation
TT+CT
No
36 (3.5)
13 (1.3)
1.000
1.000
TT+CT
Yes
879 (86.2)
894 (86.5)
0.355 (0.187-0.674)
0.412 (0.204-0.831)
CC
No
2 (0.2)
2 (0.2)
0.361 (0.046-2.838)
0.193 (0.021-1.757)
CC
Yes
103 (10.1)
124 (12.0)
0.300 (0.151-0.596)
0.410 (0.193-0.869)
rs6815391 × ventilation situation
ORmultiply (95% CI)
0.823 (0.624-1.086)
1.031 (0.466-2.281)
rs6815391 with kitchen ventilator
TT+CT
No
402 (39.4)
279 (27.0)
1.000
1.000
TT+CT
Yes
513 (50.3)
628 (60.8)
0.567 (0.468-0.687)
0.910 (0.717-1.155)
CC
No
33 (3.2)
28 (2.7)
0.818 (0.483-1.384)
0.860 (0.478-1.547)
CC
Yes
72 (7.1)
98 (9.5)
0.510 (0.363-0.717)
0.927 (0.627-1.372)
rs6815391 × kitchen ventilator
ORmultiply (95% CI)
0.725 (0.528-0.995)
0.994 (0.698-1.415)
rs6815391 with COF
TT+CT
No
150 (14.7)
290 (28.1)
1.000
1.000
TT+CT
Yes
765 (75.0)
617 (59.7)
2.397 (1.916-2.998)
1.999 (1.554-2.571)
CC
No
25 (2.5)
47 (4.5)
1.028 (0.609-1.736)
1.080 (0.614-1.900)
CC
Yes
80 (7.8)
79 (7.6)
1.958 (1.355-2.829)
1.855 (1.232-2.791)
rs6815391 × COF
ORmultiply (95% CI)
1.028 (0.744-1.421)
0.960 (0.872-1.057)
rs6815391 with smoking
TT+CT
No
349 (34.2)
536 (51.9)
1.000
1.000
TT+CT
Yes
566 (55.5)
371 (35.9)
2.343 (1.942-2.827)
2.008 (1.596-2.525)
CC
No
39 (3.8)
82 (7.9)
0.730 (0.487-1.094)
0.858 (0.555-1.328)
CC
Yes
66 (6.5)
44 (4.3)
2.304 (1.537-3.453)
2.221 (1.417-3.482)
rs6815391 × smoking
ORmultiply (95% CI)
1.555 (1.051-2.301)
1.531 (0.994-2.359)
rs6815391 with passive smoking
TT+CT
No
273 (26.8)
499 (48.3)
1.000
1.000
TT+CT
Yes
642 (62.9)
408 (39.5)
2.876 (2.372-3.488)
2.253 (1.822-2.786)
CC
No
38 (3.7)
75 (7.3)
0.926 (0.610-1.406)
0.895 (0.569-1.409)
CC
Yes
67 (6.6)
51 (4.9)
2.401 (1.621-3.557)
2.356 (1.530-3.629)
rs6815391 × passive smoking
ORmultiply (95% CI)
1.354 (0.930-1.970)
1.516 (1.000-2.300)
rs6815391 with drink alcohol
TT+CT
No
603 (59.1)
658 (63.7)
1.000
1.000
TT+CT
Yes
312 (30.6)
249 (24.1)
1.367 (1.120-1.670)
0.874 (0.686-1.112)
CC
No
71 (7.0)
91 (8.8)
0.851 (0.612-1.184)
0.981 (0.678-1.420)
CC
Yes
34 (3.3)
35 (3.4)
1.060 (0.653-1.721)
0.833 (0.484-1.435)
rs6815391 × drink alcohol
ORmultiply (95% CI)
0.983 (0.608-1.589)
0.877 (0.515-1.496)
rs6815391 with history of lung disease
TT+CT
No
800 (78.4)
841 (81.4)
1.000
1.000
TT+CT
Yes
115 (11.3)
66 (6.4)
1.832 (1.333-2.517)
1.702 (1.186-2.445)
CC
No
96 (9.4)
115 (11.1)
0.878 (0.658-1.170)
1.032 (0.748-1.424)
CC
Yes
9 (0.9)
11 (1.1)
0.860 (0.355-2.087)
0.906 (0.340-2.416)
rs6815391 × history of lung disease
ORmultiply (95% CI)
0.827 (0.341-2.004)
0.853 (0.320-2.277)
rs6815391 with family history of cancer
TT+CT
No
736 (72.2)
768 (74.3)
1.000
1.000
TT+CT
Yes
179 (17.5)
139 (13.5)
1.344 (1.053-1.714)
1.409 (1.072-1.852)
CC
No
82 (8.0)
108 (10.5)
0.792 (0.584-1.074)
0.940 (0.670-1.319)
CC
Yes
23 (2.3)
18 (1.7)
1.333 (0.714-2.491)
1.614 (0.795-3.274)
rs6815391 × family history of cancer
ORmultiply (95% CI)
1.301 (0.698-2.425)
1.535 (0.758-3.106)
rs3740535
rs3740535 with pollution near the place of residence
GA+GG
No
779 (74.3)
934 (86.6)
1.000
1.000
GA+GG
Yes
196 (18.7)
81 (7.5)
2.901 (2.202-3.823)
2.669 (1.976-3.605)
AA
No
61 (5.8)
58 (5.4)
1.261 (0.869-1.829)
1.188 (0.784-1.800)
AA
Yes
12 (1.1)
6 (0.6)
2.398 (0.896-6.419)
1.624 (0.537-4.911)
rs3740535 × pollution near the place of residence
ORmultiply (95% CI)
2.071 (0.775-5.540)
1.419 (0.470-4.289)
rs3740535 with house type
GA+GG
No
322 (30.7)
166 (15.4)
1.000
1.000
GA+GG
Yes
653 (62.3)
849 (78.7)
0.397 (0.320-0.491)
0.516 (0.403-0.661)
AA
No
33 (3.1)
12 (1.1)
1.418 (0.713-2.817)
1.232 (0.578-2.624)
AA
Yes
40 (3.8)
52 (4.8)
0.397 (0.252-0.624)
0.546 (0.331-0.898)
rs3740535 × house type
ORmultiply (95% CI)
0.784 (0.514-1.194)
0.875 (0.548-1.395)
rs3740535 with ventilation situation
GA+GG
No
37 (3.5)
13 (1.2)
1.000
1.000
GA+GG
Yes
938 (89.5)
1002 (92.9)
0.329 (0.174-0.623)
0.384 (0.191-0.773)
AA
No
2 (0.2)
3 (0.3)
0.234 (0.035-1.562)
0.109 (0.013-0.925)
AA
Yes
71 (6.8)
61 (5.7)
0.409 (0.199-0.839)
0.450 (0.204-0.992)
rs3740535 × ventilation situation
ORmultiply (95% CI)
1.213 (0.852-1.727)
1.476 (0.475-4.529)
rs3740535 with kitchen ventilator
GA+GG
No
400 (38.2)
305 (28.3)
1.000
1.000
GA+GG
Yes
575 (54.9)
710 (65.8)
0.618 (0.513-0.743)
1.013 (0.804-1.275)
AA
No
50 (4.8)
19 (1.8)
2.007 (1.159-3.474)
2.027 (1.170-3.730)
AA
Yes
23 (2.2)
45 (4.2)
0.390 (0.231-0.658)
0.656 (0.366-1.178)
rs3740535 × kitchen ventilator
ORmultiply (95% CI)
0.516 (0.310-0.858)
0.641 (0.365-1.123)
rs3740535 with COF
GA+GG
No
170 (16.2)
321 (29.7)
1.000
1.000
GA+GG
Yes
805 (76.8)
694 (64.3)
2.190 (1.772-2.707)
1.851 (1.458-2.349)
AA
No
10 (1.0)
21 (1.9)
0.899 (0.414-1.953)
0.887 (0.386-2.039)
AA
Yes
63 (6.0)
43 (4.0)
2.766 (1.800-4.253)
2.163 (1.329-3.521)
rs3740535 × COF
ORmultiply (95% CI)
1.541 (1.036-2.293)
1.017 (0.895-1.155)
rs3740535 with smoking
GA+GG
No
376 (35.9)
595 (55.1)
1.000
1.000
GA+GG
Yes
599 (57.2)
420 (38.9)
2.257 (1.886-2.701)
1.900 (1.525-2.367)
AA
No
24 (2.3)
40 (3.7)
0.949 (0.563-1.601)
0.903 (0.510-1.598)
AA
Yes
49 (4.7)
24 (2.2)
3.231 (1.950-5.354)
2.539 (1.442-4.471)
rs3740535 × smoking
ORmultiply (95% CI)
2.156 (1.313-3.540)
1.781 (1.024-3.100)
rs3740535 with passive smoking
GA+GG
No
283 (27.0)
557 (51.6)
1.000
1.000
GA+GG
Yes
692 (66.0)
458 (42.4)
2.974 (2.470-3.580)
2.406 (1.961-2.952)
AA
No
27 (2.6)
38 (3.5)
1.398 (0.837-2.337)
1.133 (0.641-2.005)
AA
Yes
46 (4.4)
26 (2.4)
3.48 2 (2.108-5.751)
2.591 (1.495-4.489)
rs3740535 × passive smoking
ORmultiply (95% CI)
1.859 (1.141-3.031)
1.560 (0.909-2.679)
rs3740535 with drink alcohol
GA+GG
No
636 (60.7)
719 (66.6)
1.000
1.000
GA+GG
Yes
339 (32.3)
296 (27.4)
1.295 (1.072-1.564)
0.847 (0.673-1.064)
AA
No
48 (4.6)
51 (4.7)
1.064 (0.707-1.601)
0.906 (0.569-1.443)
AA
Yes
25 (2.4)
13 (1.2)
2.174 (1.103-4.285)
1.566 (0.731-3.355)
rs3740535 × drink alcohol
ORmultiply (95% CI)
2.004 (1.020-3.938)
1.683 (0.791-3.577)
rs3740535 with history of lung disease
GA+GG
No
859 (82.0)
935 (86.7)
1.000
1.000
GA+GG
Yes
116 (11.1)
80 (7.4)
1.578 (1.170-2.129)
1.467 (1.043-2.064)
AA
No
64 (6.1)
55 (5.1)
1.267 (0.873-1.838)
1.199 (0.786-1.829)
AA
Yes
9 (0.9)
9 (0.8)
1.088 (0.430-2.755)
0.920 (0.320-2.644)
rs3740535 × history of lung disease
ORmultiply (95% CI)
1.030 (0.407-2.605)
0.880 (0.306-2.529)
rs3740535 with family history of cancer
GA+GG
No
783 (74.7)
866 (80.3)
1.000
1.000
GA+GG
Yes
192 (18.3)
149 (13.8)
1.425 (1.127-1.802)
1.551 (1.191-2.019)
AA
No
54 (5.2)
53 (4.9)
1.127 (0.762-1.666)
1.209 (0.779-1.874)
AA
Yes
19 (1.8)
11 (1.0)
1.910 (0.903-4.040)
1.189 (0.517-2.738)
rs3740535 × family history of cancer
ORmultiply (95% CI)
1.793 (0.849-3.786)
1.094 (0.476-2.510)
rs3130932
rs3130932 with pollution near the place of residence
GT+TT
No
728 (69.7)
867 (80.1)
1.000
1.000
GT+TT
Yes
185 (17.7)
80 (7.4)
2.754 (2.081-3.645)
2.418 (1.780-3.284)
GG
No
110 (10.5)
129 (11.9)
1.016 (0.773-1.334)
1.028 (0.757-1.396)
GG
Yes
22 (2.1)
6 (0.6)
4.367 (1.761-10.827)
4.881 (1.849-12.885)
rs3130932 × pollution near the place of residence
ORmultiply (95% CI)
3.857 (1.557-9.550)
4.354 (1.649-11.495)
rs3130932 with house type
GT+TT
No
302 (28.9)
153 (14.1)
1.000
1.000
GT+TT
Yes
611 (58.5)
794 (73.4)
0.390 (0.312-0.486)
0.542 (0.419-0.701)
GG
No
54 (5.2)
25 (2.3)
1.094 (0.656-1.827)
1.433 (0.817-2.513)
GG
Yes
78 (7.5)
110 (10.2)
0.359 (0.253-0.509)
0.535 (0.360-0.795)
rs3130932 × house type
ORmultiply (95% CI)
0.713 (0.526-0.965)
0.832 (0.591-1.171)
rs3130932 with ventilation situation
GT+TT
No
34 (3.3)
14 (1.3)
1.000
1.000
GT+TT
Yes
879 (84.1)
933 (86.2)
0.388 (0.207-0.728)
0.503 (0.253-0.998)
GG
No
4 (0.4)
1 (0.1)
1.647 (0.169-16.070)
2.456 (0.214-28.192)
GG
Yes
128 (12.2)
134 (12.4)
0.393 (0.202-0.767)
0.534 (0.257-1.110)
rs3130932 × ventilation situation
ORmultiply (95% CI)
0.988 (0.762-1.279)
1.063 (0.500-2.262)
rs3130932 with kitchen ventilator
GT+TT
No
396 (37.9)
286 (26.4)
1.000
1.000
GT+TT
Yes
517 (49.5)
661 (61.1)
0.565 (0.467-0.684)
0.926 (0.730-1.173)
GG
No
54 (5.2)
40 (3.7)
0.975 (0.630-1.508)
1.045 (0.646-1.689)
GG
Yes
78 (7.5)
95 (8.8)
0.593 (0.424-0.830)
1.040 (0.704-1.537)
rs3130932 × kitchen ventilator
ORmultiply (95% CI)
0.838 (0.613-1.145)
1.093 (0.767-1.559)
rs3130932 with COF
GT+TT
No
162 (15.5)
297 (27.4)
1.000
1.000
GT+TT
Yes
751 (71.9)
650 (60.1)
2.118 (1.703-2.635)
1.823 (1.426-2.332)
GG
No
19 (1.8)
44 (4.1)
0.792 (0.447-1.401)
1.017 (0.547-1.892)
GG
Yes
113 (10.8)
91 (8.4)
2.277 (1.627-3.185)
2.007 (1.378-2.923)
rs3130932 × COF
ORmultiply (95% CI)
1.320 (0.988-1.765)
1.013 (0.922-1.112)
rs3130932 with smoking
GT+TT
No
341 (32.6)
557 (51.5)
1.000
1.000
GT+TT
Yes
572 (54.7)
390 (36.0)
2.396 (1.988-2.886)
2.016 (1.607-2.529)
GG
No
52 (5.0)
81 (7.5)
1.049 (0.722-1.523)
1.144 (0.759-1.724)
GG
Yes
80 (7.7)
54 (5.0)
2.420 (1.671-3.505)
2.113 (1.389-3.212)
rs3130932 × smoking
ORmultiply (95% CI)
1.578 (1.105-2.253)
1.414 (0.950-2.106)
rs3130932 with passive smoking
GT+TT
No
273 (26.1)
519 (48.0)
1.000
1.000
GT+TT
Yes
640 (61.2)
428 (39.6)
2.843 (2.349-3.441)
2.296 (1.859-2.834)
GG
No
38 (3.6)
81 (7.5)
0.892 (0.591-1.347)
0.934 (0.597-1.460)
GG
Yes
94 (9.0)
54 (5.0)
3.309 (2.297-4.769)
2.835 (1.899-4.233)
rs3130932 × passive smoking
ORmultiply (95% CI)
1.882 (1.331-2.660)
1.778 (1.214-2.604)
rs3130932 with drink alcohol
GT+TT
No
592 (56.7)
678 (62.7)
1.000
1.000
GT+TT
Yes
321 (30.7)
269 (24.9)
1.367 (1.123-1.663)
0.882 (0.696-1.119)
GG
No
89 (8.5)
96 (8.9)
1.062 (0.780-1.446)
1.111 (0.785-1.573)
GG
Yes
43 (4.1)
39 (3.6)
1.263 (0.807-1.975)
0.934 (0.560-1.557)
rs3130932 × drink alcohol
ORmultiply (95% CI)
1.148 (0.738-1.786)
0.968 (0.586-1.598)
rs3130932 with history of lung disease
GT+TT
No
805 (77.0)
872 (80.6)
1.000
1.000
GT+TT
Yes
108 (10.3)
75 (6.9)
1.560 (1.144-2.126)
1.478 (1.037-2.105)
GG
No
117 (11.2)
120 (11.1)
1.056 (0.805-1.386)
1.165 (0.857-1.583)
GG
Yes
15 (1.4)
15 (1.4)
1.083 (0.526-2.230)
0.962 (0.421-2.196)
rs3130932 × history of lung disease
ORmultiply (95% CI)
1.036 (0.504-2.130)
0.914 (0.401-2.085)
rs3130932 with family history of cancer
GT+TT
No
731 (70.0)
809 (74.8)
1.000
1.000
GT+TT
Yes
182 (17.4)
138 (12.8)
1.460 (1.145-1.861)
1.484 (1.129-1.950)
GG
No
105 (10.0)
112 (10.3)
1.038 (0.781-1.379)
1.093 (0.793-1.507)
GG
Yes
27 (2.6)
23 (2.1)
1.299 (0.738-2.286)
1.632 (0.862-3.092)
rs3130932 × family history of cancer
ORmultiply (95% CI)
1.221 (0.696-2.144)
1.520 (0.805-2.873)
#By the degree of education, marital status, BMI, pollution near the place of residence, house type, ventilation situation, COF, kitchen ventilator, smoking, passive smoking, drink alcohol, history of lung disease, and family history of cancer adjusted. OR and its interval shown in italic font to represent the .