Disease Markers

Research Article

Association of Single-Nucleotide Polymorphism REX1 rs6815391, OCT4 rs13409 or rs3130932, and CTBP2 rs3740535 with Primary Lung Cancer Susceptibility: A Case-Control Study in a Chinese Population

Table 6

Joint and multiplication interaction between gene recessive model and environmental factors.


Genotype	Environment	Case (%)	Control (%)	OR (95% CI)	aOR (95% CI)^#

rs13409
rs13409 with pollution near the place of residence
CT+CC	No	736 (72.0)	866 (82.2)	1.000	1.000
CT+CC	Yes	165 (16.1)	78 (7.4)	2.489 (1.869-3.315)	2.224 (1.624-3.046)
TT	No	88 (8.6)	103 (9.8)	1.005 (0.744-1.358)	0.909 (0.649-1.272)
TT	Yes	33 (3.2)	6 (0.6)	6.471 (2.697-15.530)	6.308 (2.516-15.815)
rs13409 × pollution near the place of residence		OR^multiply (95% CI)		5.823 (2.429-13.956)	5.766 (2.302-14.444)
rs13409 with house type
CT+CC	No	303 (29.6)	156 (14.8)	1.000	1.000
CT+CC	Yes	598 (58.5)	788 (74.8)	0.402 (0.302-0.535)	0.448 (0.328-0.613)
TT	No	45 (4.4)	17 (1.6)	2.600 (1.046-6.463)	2.935 (1.131-7.617)
TT	Yes	76 (7.4)	92 (8.7)	0.404 (0.273-0.598)	0.401 (0.261-0.617)
rs13409 × house type		OR^multiply (95% CI)		1.009 (0.866-1.175)	0.846 (0.595-1.203)
rs13409 with ventilation situation
CT+CC	No	31 (3.0)	13 (1.2)	1.000	1.000
CT+CC	Yes	870 (85.1)	931 (88.4)	0.392 (0.204-0.754)	0.509 (0.248-1.045)
TT	No	5 (0.5)	2 (0.2)	1.048 (0.180-6.112)	1.311 (0.194-8.848)
TT	Yes	116 (11.4)	107 (10.2)	0.455 (0.226-0.914)	0.544 (0.252-1.175)
rs13409 × ventilation situation		OR^multiply (95% CI)		1.132 (0.857-1.495)	2.274 (1.095-4.724)
rs13409 with kitchen ventilator
CT+CC	No	381 (37.3)	275 (26.1)	1.000	1.000
CT+CC	Yes	520 (50.9)	669 (63.5)	0.561 (0.463-0.680)	0.913 (0.718-1.160)
TT	No	58 (5.7)	40 (3.8)	1.047 (0.680-1.612)	0.934 (0.577-1.512)
TT	Yes	63 (6.2)	69 (6.6)	0.659 (0.453-0.959)	1.046 (0.680-1.608)
rs13409 × kitchen ventilator		OR^multiply (95% CI)		0.937 (0.658-1.333)	1.117 (0.752-1.658)
rs13409 with COF
CT+CC	No	149 (14.6)	311 (29.5)	1.000	1.000
CT+CC	Yes	752 (73.6)	633 (60.1)	2.480 (1.986-3.096)	2.177 (1.696-2.794)
TT	No	23 (2.3)	24 (2.3)	2.000 (1.093-3.661)	2.403 (1.236-4.673)
TT	Yes	98 (9.6)	85 (8.1)	2.406 (1.696-3.415)	1.864 (1.260-2.759)
rs13409 × COF		OR^multiply (95% CI)		1.208 (0.891-1.637)	1.015 (0.916-1.124)
rs13409 with smoking
CT+CC	No	351 (34.3)	561 (53.3)	1.000	1.000
CT+CC	Yes	550 (53.8)	383 (36.4)	2.295 (1.905-2.766)	1.954 (1.559-2.450)
TT	No	40 (3.9)	64 (6.1)	0.999 (0.658-1.516)	0.935 (0.592-1.477)
TT	Yes	81 (7.9)	45 (4.3)	2.877 (1.952-4.241)	2.287 (1.468-3.563)
rs13409 × smoking		OR^multiply (95% CI)		1.928 (1.325-2.086)	1.515 (0.995-2.307)
rs13409 with passive smoking
CT+CC	No	271 (26.5)	528 (50.1)	1.000	1.000
CT+CC	Yes	630 (61.6)	416 (39.5)	2.951 (2.436-3.574)	2.403 (1.945-2.969)
TT	No	36 (3.5)	56 (5.3)	1.253 (0.804-1.925)	1.111 (0.683-1.807)
TT	Yes	85 (8.3)	53 (5.0)	3.125 (2.152-4.537)	2.445 (1.622-3.684)
rs13409 × passive smoking		OR^multiply (95% CI)		1.712 (1.201-2.440)	1.475 (0.997-2.181)
rs13409 with drink alcohol
CT+CC	No	598 (58.5)	675 (64.1)	1.000	1.000
CT+CC	Yes	303 (29.6)	269 (25.5)	1.271 (1.043-1.549)	0.829 (0.652-1.052)
TT	No	73 (7.1)	75 (7.1)	1.099 (0.782-1.544)	0.983 (0.669-1.444)
TT	Yes	48 (4.7)	34 (3.2)	1.594 (1.013-2.506)	0.992 (0.594-1.659)
rs13409 × drink alcohol		OR^multiply (95% CI)		1.477 (0.944-2.312)	1.070 (0.647-1.768)
rs13409 with history of lung disease
CT+CC	No	793 (77.6)	859 (81.6)	1.000	1.000
CT+CC	Yes	108 (10.6)	85 (8.1)	1.376 (1.019-1.858)	1.289 (0.915-1.816)
TT	No	101 (9.9)	105 (10.0)	1.042 (0.780-1.392)	0.944 (0.682-1.308)
TT	Yes	20 (2.0)	4 (0.4)	5.416 (1.843-15.914)	4.406 (1.394-13.930)
rs13409 × history of lung disease		OR^multiply (95% CI)		5.235 (1.783-15.368)	4.313 (1.366-13.620)
rs13409 with family history of cancer
CT+CC	No	714 (69.9)	805 (76.4)	1.000	1.000
CT+CC	Yes	187 (18.3)	139 (13.2)	1.517 (1.191-1.931)	1.522 (1.160-1.998)
TT	No	101 (9.9)	91 (8.6)	1.251 (0.926-1.690)	1.101 (0.784-1.546)
TT	Yes	20 (2.0)	18 (1.7)	1.253 (0.657-2.387)	1.296 (0.632-2.661)
rs13409 × family history of cancer		OR^multiply (95% CI)		1.148 (0.604-2.182)	1.197 (0.584-2.453)
rs6815391
rs6815391 with pollution near the place of residence
TT+CT	No	733 (71.9)	832 (80.5)	1.000	1.000
TT+CT	Yes	182 (17.8)	75 (7.3)	2.754 (2.068-3.669)	2.474 (1.812-3.377)
CC	No	88 (8.6)	115 (11.1)	0.869 (0.647-1.166)	1.001 (0.721-1.389)
CC	Yes	17 (1.7)	11 (1.1)	1.754 (0.816-3.769)	1.963 (0.855-4.505)
rs6815391 × pollution near the place of residence		OR^multiply (95% CI)		1.575 (0.734-3.379)	1.754 (0.764-4.026)
rs6815391 with house type
TT+CT	No	302 (29.6)	144 (13.9)	1.000	1.000
TT+CT	Yes	613 (60.1)	763 (73.9)	0.383 (0.306-0.480)	0.508 (0.391-0.661)
CC	No	32 (3.1)	21 (2.0)	0.727 (0.405-1.304)	0.844 (0.445-1.602)
CC	Yes	73 (7.2)	105 (10.2)	0.332 (0.232-0.474)	0.517 (0.344-0.777)
rs6815391 × house type		OR^multiply (95% CI)		0.681 (0.499-0.931)	0.875 (0.616-1.243)
rs6815391 with ventilation situation
TT+CT	No	36 (3.5)	13 (1.3)	1.000	1.000
TT+CT	Yes	879 (86.2)	894 (86.5)	0.355 (0.187-0.674)	0.412 (0.204-0.831)
CC	No	2 (0.2)	2 (0.2)	0.361 (0.046-2.838)	0.193 (0.021-1.757)
CC	Yes	103 (10.1)	124 (12.0)	0.300 (0.151-0.596)	0.410 (0.193-0.869)
rs6815391 × ventilation situation		OR^multiply (95% CI)		0.823 (0.624-1.086)	1.031 (0.466-2.281)
rs6815391 with kitchen ventilator
TT+CT	No	402 (39.4)	279 (27.0)	1.000	1.000
TT+CT	Yes	513 (50.3)	628 (60.8)	0.567 (0.468-0.687)	0.910 (0.717-1.155)
CC	No	33 (3.2)	28 (2.7)	0.818 (0.483-1.384)	0.860 (0.478-1.547)
CC	Yes	72 (7.1)	98 (9.5)	0.510 (0.363-0.717)	0.927 (0.627-1.372)
rs6815391 × kitchen ventilator		OR^multiply (95% CI)		0.725 (0.528-0.995)	0.994 (0.698-1.415)
rs6815391 with COF
TT+CT	No	150 (14.7)	290 (28.1)	1.000	1.000
TT+CT	Yes	765 (75.0)	617 (59.7)	2.397 (1.916-2.998)	1.999 (1.554-2.571)
CC	No	25 (2.5)	47 (4.5)	1.028 (0.609-1.736)	1.080 (0.614-1.900)
CC	Yes	80 (7.8)	79 (7.6)	1.958 (1.355-2.829)	1.855 (1.232-2.791)
rs6815391 × COF		OR^multiply (95% CI)		1.028 (0.744-1.421)	0.960 (0.872-1.057)
rs6815391 with smoking
TT+CT	No	349 (34.2)	536 (51.9)	1.000	1.000
TT+CT	Yes	566 (55.5)	371 (35.9)	2.343 (1.942-2.827)	2.008 (1.596-2.525)
CC	No	39 (3.8)	82 (7.9)	0.730 (0.487-1.094)	0.858 (0.555-1.328)
CC	Yes	66 (6.5)	44 (4.3)	2.304 (1.537-3.453)	2.221 (1.417-3.482)
rs6815391 × smoking		OR^multiply (95% CI)		1.555 (1.051-2.301)	1.531 (0.994-2.359)
rs6815391 with passive smoking
TT+CT	No	273 (26.8)	499 (48.3)	1.000	1.000
TT+CT	Yes	642 (62.9)	408 (39.5)	2.876 (2.372-3.488)	2.253 (1.822-2.786)
CC	No	38 (3.7)	75 (7.3)	0.926 (0.610-1.406)	0.895 (0.569-1.409)
CC	Yes	67 (6.6)	51 (4.9)	2.401 (1.621-3.557)	2.356 (1.530-3.629)
rs6815391 × passive smoking		OR^multiply (95% CI)		1.354 (0.930-1.970)	1.516 (1.000-2.300)
rs6815391 with drink alcohol
TT+CT	No	603 (59.1)	658 (63.7)	1.000	1.000
TT+CT	Yes	312 (30.6)	249 (24.1)	1.367 (1.120-1.670)	0.874 (0.686-1.112)
CC	No	71 (7.0)	91 (8.8)	0.851 (0.612-1.184)	0.981 (0.678-1.420)
CC	Yes	34 (3.3)	35 (3.4)	1.060 (0.653-1.721)	0.833 (0.484-1.435)
rs6815391 × drink alcohol		OR^multiply (95% CI)		0.983 (0.608-1.589)	0.877 (0.515-1.496)
rs6815391 with history of lung disease
TT+CT	No	800 (78.4)	841 (81.4)	1.000	1.000
TT+CT	Yes	115 (11.3)	66 (6.4)	1.832 (1.333-2.517)	1.702 (1.186-2.445)
CC	No	96 (9.4)	115 (11.1)	0.878 (0.658-1.170)	1.032 (0.748-1.424)
CC	Yes	9 (0.9)	11 (1.1)	0.860 (0.355-2.087)	0.906 (0.340-2.416)
rs6815391 × history of lung disease		OR^multiply (95% CI)		0.827 (0.341-2.004)	0.853 (0.320-2.277)
rs6815391 with family history of cancer
TT+CT	No	736 (72.2)	768 (74.3)	1.000	1.000
TT+CT	Yes	179 (17.5)	139 (13.5)	1.344 (1.053-1.714)	1.409 (1.072-1.852)
CC	No	82 (8.0)	108 (10.5)	0.792 (0.584-1.074)	0.940 (0.670-1.319)
CC	Yes	23 (2.3)	18 (1.7)	1.333 (0.714-2.491)	1.614 (0.795-3.274)
rs6815391 × family history of cancer		OR^multiply (95% CI)		1.301 (0.698-2.425)	1.535 (0.758-3.106)
rs3740535
rs3740535 with pollution near the place of residence
GA+GG	No	779 (74.3)	934 (86.6)	1.000	1.000
GA+GG	Yes	196 (18.7)	81 (7.5)	2.901 (2.202-3.823)	2.669 (1.976-3.605)
AA	No	61 (5.8)	58 (5.4)	1.261 (0.869-1.829)	1.188 (0.784-1.800)
AA	Yes	12 (1.1)	6 (0.6)	2.398 (0.896-6.419)	1.624 (0.537-4.911)
rs3740535 × pollution near the place of residence		OR^multiply (95% CI)		2.071 (0.775-5.540)	1.419 (0.470-4.289)
rs3740535 with house type
GA+GG	No	322 (30.7)	166 (15.4)	1.000	1.000
GA+GG	Yes	653 (62.3)	849 (78.7)	0.397 (0.320-0.491)	0.516 (0.403-0.661)
AA	No	33 (3.1)	12 (1.1)	1.418 (0.713-2.817)	1.232 (0.578-2.624)
AA	Yes	40 (3.8)	52 (4.8)	0.397 (0.252-0.624)	0.546 (0.331-0.898)
rs3740535 × house type		OR^multiply (95% CI)		0.784 (0.514-1.194)	0.875 (0.548-1.395)
rs3740535 with ventilation situation
GA+GG	No	37 (3.5)	13 (1.2)	1.000	1.000
GA+GG	Yes	938 (89.5)	1002 (92.9)	0.329 (0.174-0.623)	0.384 (0.191-0.773)
AA	No	2 (0.2)	3 (0.3)	0.234 (0.035-1.562)	0.109 (0.013-0.925)
AA	Yes	71 (6.8)	61 (5.7)	0.409 (0.199-0.839)	0.450 (0.204-0.992)
rs3740535 × ventilation situation		OR^multiply (95% CI)		1.213 (0.852-1.727)	1.476 (0.475-4.529)
rs3740535 with kitchen ventilator
GA+GG	No	400 (38.2)	305 (28.3)	1.000	1.000
GA+GG	Yes	575 (54.9)	710 (65.8)	0.618 (0.513-0.743)	1.013 (0.804-1.275)
AA	No	50 (4.8)	19 (1.8)	2.007 (1.159-3.474)	2.027 (1.170-3.730)
AA	Yes	23 (2.2)	45 (4.2)	0.390 (0.231-0.658)	0.656 (0.366-1.178)
rs3740535 × kitchen ventilator		OR^multiply (95% CI)		0.516 (0.310-0.858)	0.641 (0.365-1.123)
rs3740535 with COF
GA+GG	No	170 (16.2)	321 (29.7)	1.000	1.000
GA+GG	Yes	805 (76.8)	694 (64.3)	2.190 (1.772-2.707)	1.851 (1.458-2.349)
AA	No	10 (1.0)	21 (1.9)	0.899 (0.414-1.953)	0.887 (0.386-2.039)
AA	Yes	63 (6.0)	43 (4.0)	2.766 (1.800-4.253)	2.163 (1.329-3.521)
rs3740535 × COF		OR^multiply (95% CI)		1.541 (1.036-2.293)	1.017 (0.895-1.155)
rs3740535 with smoking
GA+GG	No	376 (35.9)	595 (55.1)	1.000	1.000
GA+GG	Yes	599 (57.2)	420 (38.9)	2.257 (1.886-2.701)	1.900 (1.525-2.367)
AA	No	24 (2.3)	40 (3.7)	0.949 (0.563-1.601)	0.903 (0.510-1.598)
AA	Yes	49 (4.7)	24 (2.2)	3.231 (1.950-5.354)	2.539 (1.442-4.471)
rs3740535 × smoking		OR^multiply (95% CI)		2.156 (1.313-3.540)	1.781 (1.024-3.100)
rs3740535 with passive smoking
GA+GG	No	283 (27.0)	557 (51.6)	1.000	1.000
GA+GG	Yes	692 (66.0)	458 (42.4)	2.974 (2.470-3.580)	2.406 (1.961-2.952)
AA	No	27 (2.6)	38 (3.5)	1.398 (0.837-2.337)	1.133 (0.641-2.005)
AA	Yes	46 (4.4)	26 (2.4)	3.48 2 (2.108-5.751)	2.591 (1.495-4.489)
rs3740535 × passive smoking		OR^multiply (95% CI)		1.859 (1.141-3.031)	1.560 (0.909-2.679)
rs3740535 with drink alcohol
GA+GG	No	636 (60.7)	719 (66.6)	1.000	1.000
GA+GG	Yes	339 (32.3)	296 (27.4)	1.295 (1.072-1.564)	0.847 (0.673-1.064)
AA	No	48 (4.6)	51 (4.7)	1.064 (0.707-1.601)	0.906 (0.569-1.443)
AA	Yes	25 (2.4)	13 (1.2)	2.174 (1.103-4.285)	1.566 (0.731-3.355)
rs3740535 × drink alcohol		OR^multiply (95% CI)		2.004 (1.020-3.938)	1.683 (0.791-3.577)
rs3740535 with history of lung disease
GA+GG	No	859 (82.0)	935 (86.7)	1.000	1.000
GA+GG	Yes	116 (11.1)	80 (7.4)	1.578 (1.170-2.129)	1.467 (1.043-2.064)
AA	No	64 (6.1)	55 (5.1)	1.267 (0.873-1.838)	1.199 (0.786-1.829)
AA	Yes	9 (0.9)	9 (0.8)	1.088 (0.430-2.755)	0.920 (0.320-2.644)
rs3740535 × history of lung disease		OR^multiply (95% CI)		1.030 (0.407-2.605)	0.880 (0.306-2.529)
rs3740535 with family history of cancer
GA+GG	No	783 (74.7)	866 (80.3)	1.000	1.000
GA+GG	Yes	192 (18.3)	149 (13.8)	1.425 (1.127-1.802)	1.551 (1.191-2.019)
AA	No	54 (5.2)	53 (4.9)	1.127 (0.762-1.666)	1.209 (0.779-1.874)
AA	Yes	19 (1.8)	11 (1.0)	1.910 (0.903-4.040)	1.189 (0.517-2.738)
rs3740535 × family history of cancer		OR^multiply (95% CI)		1.793 (0.849-3.786)	1.094 (0.476-2.510)
rs3130932
rs3130932 with pollution near the place of residence
GT+TT	No	728 (69.7)	867 (80.1)	1.000	1.000
GT+TT	Yes	185 (17.7)	80 (7.4)	2.754 (2.081-3.645)	2.418 (1.780-3.284)
GG	No	110 (10.5)	129 (11.9)	1.016 (0.773-1.334)	1.028 (0.757-1.396)
GG	Yes	22 (2.1)	6 (0.6)	4.367 (1.761-10.827)	4.881 (1.849-12.885)
rs3130932 × pollution near the place of residence		OR^multiply (95% CI)		3.857 (1.557-9.550)	4.354 (1.649-11.495)
rs3130932 with house type
GT+TT	No	302 (28.9)	153 (14.1)	1.000	1.000
GT+TT	Yes	611 (58.5)	794 (73.4)	0.390 (0.312-0.486)	0.542 (0.419-0.701)
GG	No	54 (5.2)	25 (2.3)	1.094 (0.656-1.827)	1.433 (0.817-2.513)
GG	Yes	78 (7.5)	110 (10.2)	0.359 (0.253-0.509)	0.535 (0.360-0.795)
rs3130932 × house type		OR^multiply (95% CI)		0.713 (0.526-0.965)	0.832 (0.591-1.171)
rs3130932 with ventilation situation
GT+TT	No	34 (3.3)	14 (1.3)	1.000	1.000
GT+TT	Yes	879 (84.1)	933 (86.2)	0.388 (0.207-0.728)	0.503 (0.253-0.998)
GG	No	4 (0.4)	1 (0.1)	1.647 (0.169-16.070)	2.456 (0.214-28.192)
GG	Yes	128 (12.2)	134 (12.4)	0.393 (0.202-0.767)	0.534 (0.257-1.110)
rs3130932 × ventilation situation		OR^multiply (95% CI)		0.988 (0.762-1.279)	1.063 (0.500-2.262)
rs3130932 with kitchen ventilator
GT+TT	No	396 (37.9)	286 (26.4)	1.000	1.000
GT+TT	Yes	517 (49.5)	661 (61.1)	0.565 (0.467-0.684)	0.926 (0.730-1.173)
GG	No	54 (5.2)	40 (3.7)	0.975 (0.630-1.508)	1.045 (0.646-1.689)
GG	Yes	78 (7.5)	95 (8.8)	0.593 (0.424-0.830)	1.040 (0.704-1.537)
rs3130932 × kitchen ventilator		OR^multiply (95% CI)		0.838 (0.613-1.145)	1.093 (0.767-1.559)
rs3130932 with COF
GT+TT	No	162 (15.5)	297 (27.4)	1.000	1.000
GT+TT	Yes	751 (71.9)	650 (60.1)	2.118 (1.703-2.635)	1.823 (1.426-2.332)
GG	No	19 (1.8)	44 (4.1)	0.792 (0.447-1.401)	1.017 (0.547-1.892)
GG	Yes	113 (10.8)	91 (8.4)	2.277 (1.627-3.185)	2.007 (1.378-2.923)
rs3130932 × COF		OR^multiply (95% CI)		1.320 (0.988-1.765)	1.013 (0.922-1.112)
rs3130932 with smoking
GT+TT	No	341 (32.6)	557 (51.5)	1.000	1.000
GT+TT	Yes	572 (54.7)	390 (36.0)	2.396 (1.988-2.886)	2.016 (1.607-2.529)
GG	No	52 (5.0)	81 (7.5)	1.049 (0.722-1.523)	1.144 (0.759-1.724)
GG	Yes	80 (7.7)	54 (5.0)	2.420 (1.671-3.505)	2.113 (1.389-3.212)
rs3130932 × smoking		OR^multiply (95% CI)		1.578 (1.105-2.253)	1.414 (0.950-2.106)
rs3130932 with passive smoking
GT+TT	No	273 (26.1)	519 (48.0)	1.000	1.000
GT+TT	Yes	640 (61.2)	428 (39.6)	2.843 (2.349-3.441)	2.296 (1.859-2.834)
GG	No	38 (3.6)	81 (7.5)	0.892 (0.591-1.347)	0.934 (0.597-1.460)
GG	Yes	94 (9.0)	54 (5.0)	3.309 (2.297-4.769)	2.835 (1.899-4.233)
rs3130932 × passive smoking		OR^multiply (95% CI)		1.882 (1.331-2.660)	1.778 (1.214-2.604)
rs3130932 with drink alcohol
GT+TT	No	592 (56.7)	678 (62.7)	1.000	1.000
GT+TT	Yes	321 (30.7)	269 (24.9)	1.367 (1.123-1.663)	0.882 (0.696-1.119)
GG	No	89 (8.5)	96 (8.9)	1.062 (0.780-1.446)	1.111 (0.785-1.573)
GG	Yes	43 (4.1)	39 (3.6)	1.263 (0.807-1.975)	0.934 (0.560-1.557)
rs3130932 × drink alcohol		OR^multiply (95% CI)		1.148 (0.738-1.786)	0.968 (0.586-1.598)
rs3130932 with history of lung disease
GT+TT	No	805 (77.0)	872 (80.6)	1.000	1.000
GT+TT	Yes	108 (10.3)	75 (6.9)	1.560 (1.144-2.126)	1.478 (1.037-2.105)
GG	No	117 (11.2)	120 (11.1)	1.056 (0.805-1.386)	1.165 (0.857-1.583)
GG	Yes	15 (1.4)	15 (1.4)	1.083 (0.526-2.230)	0.962 (0.421-2.196)
rs3130932 × history of lung disease		OR^multiply (95% CI)		1.036 (0.504-2.130)	0.914 (0.401-2.085)
rs3130932 with family history of cancer
GT+TT	No	731 (70.0)	809 (74.8)	1.000	1.000
GT+TT	Yes	182 (17.4)	138 (12.8)	1.460 (1.145-1.861)	1.484 (1.129-1.950)
GG	No	105 (10.0)	112 (10.3)	1.038 (0.781-1.379)	1.093 (0.793-1.507)
GG	Yes	27 (2.6)	23 (2.1)	1.299 (0.738-2.286)	1.632 (0.862-3.092)
rs3130932 × family history of cancer		OR^multiply (95% CI)		1.221 (0.696-2.144)	1.520 (0.805-2.873)

^#By the degree of education, marital status, BMI, pollution near the place of residence, house type, ventilation situation, COF, kitchen ventilator, smoking, passive smoking, drink alcohol, history of lung disease, and family history of cancer adjusted. OR and its interval shown in italic font to represent the .