Combined Immunohistochemistry for the “Three 7” Markers (CK7, CD117, and Claudin-7) Is Useful in the Diagnosis of Chromophobe Renal Cell Carcinoma and for the Exclusion of Mimics: Diagnostic Experience from a Single Institution

<div>Exceptional cases with diffuse and strong immunostaining for some of the “three 7” markers in CCRCC and PRCC. Herein, 2 distinct cases of CCRCC show bright CK7 (a) and Claudin-7 (b) immunostaining, respectively. Rare cases of PRCC can show diffuse and strong positivity for Claudin-7 (c). Both CCRCC and PRCC are consistently negative for CD117. This rare case of RO shows diffuse and intense Claudin-7 (d) expression.</div>

Disease Markers

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Figure 4

Figure 4: Combined Immunohistochemistry for the “Three 7” Markers (CK7, CD117, and Claudin-7) Is Useful in the Diagnosis of Chromophobe Renal Cell Carcinoma and for the Exclusion of Mimics: Diagnostic Experience from a Single Institution 

Figure 4 | Combined Immunohistochemistry for the “Three 7” Markers (CK7, CD117, and Claudin-7) Is Useful in the Diagnosis of Chromophobe Renal Cell Carcinoma and for the Exclusion of Mimics: Diagnostic Experience from a Single Institution 