Combined Immunohistochemistry for the “Three 7” Markers (CK7, CD117, and Claudin-7) Is Useful in the Diagnosis of Chromophobe Renal Cell Carcinoma and for the Exclusion of Mimics: Diagnostic Experience from a Single Institution

<div>Miscellaneous immunohistochemical features of CK7 and Claudin-7 in some negative cases of CCRCC and RO. Very focal (&lt;10%) and mild-to-moderate staining for CK7 or Claudin-7 can be found in some tumor cells located on the wall of cystic structures (CCRCC: (a) CK7; (b) Claudin-7) or within sclerotic/edematous stroma (RO: (c) CK7; (d) Claudin-7) in some “three 7”-negative cases of CCRCC or RO.</div>

Disease Markers

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Figure 5

Figure 5: Combined Immunohistochemistry for the “Three 7” Markers (CK7, CD117, and Claudin-7) Is Useful in the Diagnosis of Chromophobe Renal Cell Carcinoma and for the Exclusion of Mimics: Diagnostic Experience from a Single Institution 

Figure 5 | Combined Immunohistochemistry for the “Three 7” Markers (CK7, CD117, and Claudin-7) Is Useful in the Diagnosis of Chromophobe Renal Cell Carcinoma and for the Exclusion of Mimics: Diagnostic Experience from a Single Institution 