Serum Levels of miR-143 Predict Survival in Critically Ill Patients

Figure 3

Low serum levels of miR-143 indicate an unfavorable outcome in critically ill patients treated on a medical ICU. (a) Serum levels of miR-143 were analyzed by qPCR in critically ill patients that survived their ICU stay or succumbed to death. Patients that survived had significantly higher miR-143 serum levels on admittance to the ICU than those patients that succumbed to death. (b) Kaplan-Meier survival curves of ICU patients are displayed, showing that patients with miR-143 levels within the lowest quartile of all patients displayed the lowest short-term survival at the ICU. (c) The Youden index was used to calculate the optimal threshold to distinguish between survivors and patients that died during ICU treatment. The Kaplan-Meier survival curve analyses revealed that patients with miR-143 below this threshold displayed a significantly impaired prognosis. Significances are given in the figure. (d) The ROC curve analysis comparing the prognostic value of miR-143 with that of other markers routinely accessed in the context of critical illness.

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