Serum Levels of miR-143 Predict Survival in Critically Ill Patients

Figure 4

Low miR-143 serum concentrations are associated with an impaired long-term prognosis of critically ill patients. (a) Patients that succumbed to death during long-term follow-up had lower serum miR-143 levels on admittance to the ICU (, -test) compared to patients that survived. (b) Kaplan-Meier curve analysis revealing that patients with miR-143 concentrations within the lower quartile had an increased overall mortality as compared to patients with miR-143 serum concentrations of the highest quartile. (c) The Youden index was used to calculate the optimal threshold to distinguish between survivors and patients that died during long-term follow-up. The Kaplan-Meier survival curve analyses revealed that patients with miR-143 below this threshold displayed a significantly impaired prognosis. (d) ROC curve analysis comparing the prognostic value of miR-143 with that of other markers routinely accessed in the context of critical illness.

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