Plasma Fibrin Clot Properties Are Unfavorably Altered in Women following Venous Thromboembolism Associated with Combined Hormonal Contraception
Table 1
Characteristics of the studied groups.
Variable
Contraception-related VTE ()
Unprovoked VTE ()
Control group ()
value
Age (years)
0.9
BMI (kg/m2)
0.06
Cigarette smoking, (%)
21 (44)
15 (32)
16 (33)
0.4
Family history of VTE, (%)
11 (23)
9 (19)
4 (8)
0.14
Obesity, (%)
11 (23)
10 (21)
5 (10)
0.33
Arterial hypertension, (%)
4 (8)
14 (29)
11 (23)
0.03
Diabetes mellitus, (%)
1 (2)
2 (4)
3 (6)
0.59
Laboratory parameters
Fibrinogen (g/L)
2.89 (2.48-3.73)
2.90 (2.36-3.290)
2.76 (2.34-3.42)
0.77
INR
0.89
Creatinine (μmol/L)
0.36
Glucose (mmol/L)
4.95 (4.60-5.45)
4.80 (4.45-5.35)
5.20 (4.80-5.85)
0.60
TG (mmol/L)
1.25 (0.77-1.73)
1.31 (0.85-1.85)
1.18 (0.82-1.61)
0.04
TC (mmol/L)
0.07
HDL-C (mmol/L)
0.20
LDL-C (mmol/L)
0.04
hsCRP (mg/L)
1.18 (0.93-1.78)
1.79 (1.15-2.37)
1.51 (0.91-2.25)
0.11
D-dimer (ng/mL)
272 (212-359)
279 (219-341)
247 (210-300)
0.10
Plasminogen (%)
0.78
α2-Antiplasmin
0.06
Genetic polymorphisms, (%)
Factor XIII Val34Leu
23 (48)
16 (33)
10 (21)
0.04
α-Fibrinogen Thr312Ala
21 (44)
22 (46)
14 (29)
0.30
Factor V Leiden
8 (17)
7 (15)
2 (4)
0.13
Prothrombin 20210A mutation
2 (4)
2 (4)
2 (4)
1.00
Data are shown as , median (interquartile range) or number (percentage). Abbreviations: HDL-C, high-density lipoprotein cholesterol; hsCRP, high-sensitivity C-reactive protein; INR, international normalized ratio; LDL-C, low-density lipoprotein cholesterol; TC, total cholesterol; TG, triglycerides; and VTE, venous thromboembolism.
