A Genomic-Clinicopathologic Nomogram Predicts Survival for Patients with Laryngeal Squamous Cell Carcinoma
Table 2
Univariable and multivariable Cox regression analysis for prediction of OS.
Factors
Subgroup
Univariable analysis
Multivariable analysis
HR (95% CI)
HR (95% CI)
Age
1.00 (0.97-1.04)
0.984
NA
NA
Sex
Female
1
Male
0.28 (0.14-0.56)
0.001
0.45 (0.31-1.07)
0.090
Smoking history
No
1
Yes
0.65 (0.35-1.18)
0.156
NA
NA
Alcohol history
No
1
Yes
0.77 (0.43-1.39)
0.388
NA
NA
Number of lymph nodes
1.00 (0.98-1.01)
0.558
NA
NA
Number of positive LNs
1.00 (0.95-1.04)
0.892
NA
NA
Lymph node ratio
1.41 (0.28-7.13)
0.675
NA
NA
Margin status
Negative
1
1
Positive
4.68 (2.08-10.51)
0.001
3.00 (1.47-6.10)
0.003
Tumor status
Tumor free
1
1
With tumor
4.10 (2.23-7.55)
0.001
3.25 (1.79-5.90)
0.001
Tumor grade
G1-G2
1
G3-G4
0.51 (0.25-1.04)
0.064
NA
NA
Clinical T
T1-T2
1
T3-T4
0.72 (0.35-1.50)
0.376
NA
NA
Clinical N
N0
1
N1-N3
1.44 (0.80-2.57)
0.222
NA
NA
Clinical stage
I-II
1
III-IV
0.86 (0.36-2.03)
0.729
NA
NA
Mutation count
0.99 (0.98-1.01)
0.542
NA
NA
Fraction genome altered
1.44 (0.29-7.18)
0.654
NA
NA
lncRNA signature
1.22 (1.14-1.31)
0.001
1.21 (1.11-1.31)
0.001
Abbreviations: HR=hazard ratio; CI=confidence intervals; OS=overall survival; NA=not available. These variables were eliminated in the multivariate Cox regression model, so the HR and values were not available. .
