DNA Methylation Profiles and Their Diagnostic Utility in BC

Table 2

Methylation frequencies of the same genes in the matched serum and methylation-positive BC tissues.

Methylated gene	Breast cancer tissue (validation test, 194 cases)		Methylation frequency (%)	Matched serum		Methylation frequency (%)
	Methyl case	Unmethyl case		Methyl case	Unmethyl case
SFN	61	133	31.44	35	26	57.38
HOXA11	88	106	45.36	15	73	17.01
P16	86	108	44.33	48	38	55.81
RASSF1a	117	77	60.31	43	74	36.75
PCDHGB7	156	38	80.41	79	77	50.64
hMLH1	69	125	35.57	23	46	33.33
Wnt5a	57	137	29.38	12	45	21.05
HOXD13	90	104	46.39	1	89	1.11
RARβ	71	123	36.6	3	68	4.23