Review Article
Accuracy Evaluation of Circular RNA in Diagnosing Lung Cancer in a Chinese Population
Table 3
Summary results of the subgroup analysis for circRNAs in diagnosing lung cancer.
| | Number of studies | Sensitivity (95% CI) | Specificity (95% CI) | PLR (95% CI) | NLR (95% CI) | DOR (95% CI) | AUC |
| Sample size | | | | | | | | Blood | 4 | 0.72 (0.66–0.78) | 0.78 (0.66–0.87) | 3.30 (2.12–5.15) | 0.35 (0.29–0.43) | 9.32 (5.35–16.23) | 0.78 | Tissue | 6 | 0.80 (0.75–0.84) | 0.75 (0.66–0.82) | 3.16 (2.22–4.49) | 0.27 (0.20–0.36) | 11.67 (6.36–21.39) | 0.84 | Lung cancer | | | | | | | | Non-small-cell lung cancer | 6 | 0.78 (0.73–0.83) | 0.70 (0.66–0.79) | 2.87 (2.22–3.72) | 0.30 (0.23–0.38) | 9.66 (6.00–15.55) | 0.82 | Lung adenocarcinoma | 4 | 0.75 (0.69–0.79) | 0.81 (0.68–0.90) | 3.93 (2.20–7.03) | 0.31 (0.25–0.40) | 12.54 (5.96–26.39) | 0.76 | Reference gene | | | | | | | | GAPDH | 9 | 0.76 (0.72–0.79) | 0.75 (0.68–0.81) | 3.00 (2.31–3.90) | 0.33 (0.28–0.38) | 9.41 (6.66–13.31) | 0.77 | circRNA expression upregulation | 8 | 0.76 (0.72–0.80) | 0.77 (0.69–0.84) | 3.38 (2.39–4.77) | 0.31 (0.25–0.38) | 10.96 (6.57–18.29) | 0.79 |
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Note: PLR: positive likelihood ratio; NLR: negative likelihood ratio; AUC: area under the receiver operating characteristic curve.
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