Research Article
Expression of LGR5, FZD7, TROY, and MIST1 in Perioperatively Treated Gastric Carcinomas and Correlation with Therapy Response
Table 2
Correlation of LGR5 and MIST1 expression in primary resected gastric cancer and pretherapeutic biopsies, respectively, with tumor regression.
| | Valid | Primary resected tumor | Pretherapeutic biopsy | | LGR5 score 0-6 | MIST1 score 0-6 | | Low (0-4) | High (5-6) | Negative (0) | Positive (2-6) | | (%) | | (%) | | (%) | | (%) | | (%) |
| | Vital tumor residuals | | (1) | | | 101 | | | <0.001# | 23 | | | 0.048 | | <Median (0-54%) | | | 59 | (49.6) | 34 | (79.1) | 9 | (20.9) | 9 | (100.0) | 0 | (0.0) | | ≥Median (55-100%) | | | 60 | (50.4) | 24 | (41.4) | 34 | (58.6) | 8 | (57.1) | 6 | (42.9) | | Vital tumor residuals | | (2) | | | 101 | | | <0.001# | 23 | | | 0.012 | | Quartile 1 (0-4%) | | | 23 | (19.3) | 8 | (100.0) | 0 | (0.0) | 3 | (100.0) | 0 | (0.0) | | Quartile 2 (5-54%) | | | 36 | (30.3) | 26 | (74.3) | 9 | (25.7) | 6 | (100.0) | 0 | (0.0) | | Quartile 3 (55-89%) | | | 29 | (24.4) | 14 | (50.0) | 14 | (50.0) | 4 | (80.0) | 1 | (20.0) | | Quartile 4 (90-100%) | | | 31 | (26.1) | 10 | (33.3) | 20 | (66.7) | 4 | (44.4) | 5 | (55.6) | | Becker regression score | | (2) | | | 101 | | | <0.001# | 23 | | | 0.046 | | 1a | | | 13 | (10.9) | | | | | 2 | (100.0) | 0 | (0.0) | | 1b | | | 25 | (21.0) | 19 | (82.6) | 4 | (17.4) | 2 | (100.0) | 0 | (0.0) | | 2 | | | 19 | (16.0) | 13 | (72.2) | 5 | (27.8) | 5 | (100.0) | 0 | (0.0) | | 3 | | | 62 | (52.1) | 26 | (43.3) | 34 | (56.7) | 8 | (57.1) | 6 | (42.9) |
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(1)Fisher’s exact test; (2)Kendall’s tau test; #significant after multiple testing.
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