Review Article
Circulating MicroRNAs as Prognostic Molecular Biomarkers in Human Head and Neck Cancer: A Systematic Review and Meta-Analysis
Table 2
Overview characteristics of the selected study in systematic review and meta-analysis.
| | S. no. | Study | Population | Study period | Sample number (patient/control) | Source of miRNA | miRNA/dysregulation | Cancer site | Histological stage | Tumor grade | Lymph node metastasis | miRNA analysis platform | Follow-up |
| | 1 | Romeo et al. [33] | Italy | 2011-2015 | 26/19 | Plasma | miR-375/upregulated | Medullary thyroid | ; ; | N/A | ; ; | qRT-PCR | 80 months |
| | 2 | Sun et al. [34] | China | June 2004-June 2014 | 80/80 | Plasma | miR-200b-3p/upregulated | Oral cavity | ; | ; | N/A | qRT-PCR | >5 years |
| | 3 | Lu et al. [35] | China | 2007-2015 | 110/60 | Plasma | miR-9/downregulated | Nasopharynx | ; ; ; | ; ; | ; | qRT-PCR | 60 months |
| | 4 | Liu et al. [36] | Taiwan | N/A | 63/26 | Plasma | miR-187/downregulated | ; ; | ; | ; | ; | qRT-PCR | 46.2 months |
| | 5 | Ye et al. [37] | China | 2011-2014 | 65/20 | Serum | miR-24-3p/upregulated | Nasopharynx | ; | ; | ; | qRT-PCR | 50 months |
| | 6 | Sun et al. [38] | China | N/A | 104/40 | Serum | miR-9/downregulated | ; | ; | ; | ; | qRT-PCR | 5 years |
| | 7 | Xu et al. [39] | China | June 2008-September 2010 | 101/103 | Serum | miR-483-5p/upregulated | Oral cavity | ; | N/A | N/A | qRT-PCR | 52.16 months |
| | 8 | Qui et al. [40] | China | July 2011-August 2012 | 193/65 | Serum | miR-29b/upregulated | Nasopharynx | N/A | N/A | M193 | qRT-PCR | 5 years |
| | 9 | Summerer et al. [41] | Germany | N/A | 18/12 | Plasma | miR-191-5p/upregulated; mir-374b-5p/upregulated; miR-425-5p/upregulated | ; ; ; ; ; ; | ; ; ; | N/A | ; ;
; | qRT-PCR | 55.1 weeks |
| | 10 | Liu et al. [42] | China | January 2001-December 2006 | 512 | Serum | miR-22/upregulated; miR-572/upregulated; miR-638/upregulated; miR-1234/upregulated | Nasopharynx | ; ; ; | N/A | | Microarray/qRT-PCR | 5 years |
| | 11 | Wang et al. [41] | China | January 2009-April 2009 | 50/50 | Plasma | miR-483-5p/upregulated; miR-103/upregulated; miR-29a/upregulated; miR-let-7c/upregulated | Nasopharynx | ; | N/A | N/A | qRT-PCR | 77 months |
| | 12 | Liu et al. [44] | Taiwan | N/A | 95/24 | Plasma | miR-196a/upregulated | ; ; | ; | ; | ; | qRT-PCR | 32 months |
| | 13 | Zeng et al. [45] | China | N/A | 160/143 | Serum | miR-17/upregulated; miR-20a/upregulated; miR-29c/downregulated; miR-223/downregulated | Nasopharynx | ; ; ; | N/A | N/A | qRT-PCR | 35 months |
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miRNA/miR: microribonucleic acid; qRT-PCR: quantitative real-time polymerase chain reaction; U: unknown; N: nodal; M: metastasis; N/A: not available; NNM: no nodal metastasis.
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