Research Article
Diagnostic Accuracy of circRNAs in Esophageal Cancer: A Meta-Analysis
Table 1
Main characteristics of the included studies in this meta-analysis.
| References | Year | Country | Case/control | circRNAs | Regulation | Cancer type | Specimen | Sensitivity (%) | Specificity (%) | AUC | TP | FP | FN | TN | QUADAS-2 |
| Rong et al. | 2018 | China | 35/28 | circ-DLG1 | Upregulated | ESCC | Plasma | 83.0 | 50.0 | 0.648 | 29 | 14 | 6 | 14 | 7 | Fan et al. | 2019 | China | 50/50 | hsa_circ_0001946 | Downregulated | ESCC | Plasma | 92.0 | 80.0 | 0.894 | 46 | 10 | 4 | 40 | 8 | | | | | hsa_circ_0062459 | Downregulated | ESCC | Plasma | 64.0 | 92.0 | 0.836 | 32 | 4 | 18 | 46 | | Wang et al. | 2019 | China | 30/25 | circ-TTC17 | Upregulated | ESCC | Plasma | 73.3 | 88.0 | 0.820 | 22 | 3 | 8 | 22 | 7 | Zhang et al. | 2019 | China | 32/25 | circ-SMAD7 | Downregulated | ESCC | Plasma | 78.0 | 96.0 | 0.859 | 25 | 1 | 7 | 24 | 6 |
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ESCC: esophageal squamous cell carcinoma; AUC: area under the receiver operating characteristic curve; TP: true positive; FP: false positive; FN: false negative; TN: true negative.
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