Clinical and Prognostic Implications of P21 (WAF1/CIP1) Expression in Patients with Esophageal Cancer: A Systematic Review and Meta-Analysis

Table 1

Characteristics of studies included in the meta-analysis.

Study and year	Year	Cancer	Sample size	Country	Specimen type	Cutoff value	Method	NOS quality score
Wu 1995	1995	Esophageal cancer	40	China	Tissue	NA	Immunohistochemistry	7
Ohashi 1997	1997	SCC	25	Japan	Tissue	NA	Immunohistochemistry	6
Toh 1997	1997	SCC	61	Japan	Tissue	10%	Immunohistochemistry	7
Jiang 1998	1998	SCC	46	China	Tissue	10%	Immunohistochemistry	7
Sarbia 1998	1998	SCC (surgical treatment)	149	Germany	Tissue	50%	Immunohistochemistry	9
Kuwahara 1999	1999	SCC	32	Japan	Tissue	10%	Immunohistochemistry	8
Lam 1999	1999	SCC	153	Hong Kong	Tissue	50%	Immunohistochemistry	7
Natsugoe 1999	1999	SCC	111	Japan	Tissue	10%	Immunohistochemistry	8
Nita 1999	1999	SCC	62	Japan	Tissue	14	Immunohistochemistry	9
Shimada 1999	1999	SCC	116	Japan	Tissue	50%	Immunohistochemistry	8
Zhang 1999	1999	Esophageal cancer	38	China	Tissue	5%	Immunohistochemistry	9
Fan 2000	2000	Esophageal cancer	56	China	Tissue	NA	Immunohistochemistry	7
Liu 2000	2000	SCC	80	China	Tissue	1%	Immunohistochemistry	8
Nakashida 2000	2000	SCC	30	Japan	Tissue	10%	Immunohistochemistry	7
Matsumoto 2001	2001	SCC	79	Japan	Tissue	10%	Immunohistochemistry	7
Zhan 2001	2001	Esophageal cancer	30	China	Tissue	10%	Immunohistochemistry	6
Li 2002	2002	AD	35	China	Tissue	NA	Immunohistochemistry	6
Cui 2003	2003	SCC	72	China	Tissue	5%	Immunohistochemistry	8
Guner 2003	2003	SCC	63	Germany	Tissue	10%	Immunohistochemistry	7
Zhang 2003	2003	SCC	43	China	Tissue	0%	Immunohistochemistry	7
Li 2004	2004	SCC	80	China	Tissue	25%	Immunohistochemistry	8
Li Li 2004	2004	SCC	48	China	Tissue	NA	Immunohistochemistry, ISH	6
Nakamura 2004	2004	SCC	76	Japan	Tissue	10%	Immunohistochemistry	9
Chang 2005	2005	Esophageal cancer	118	Korea	Tissue	10%	Immunohistochemistry	7
Goan 2005	2005	SCC	36	China	Tissue	50%	Immunohistochemistry	8
Gu 2005	2005	SCC (single surgery)	50	China	Tissue	10%	Immunohistochemistry	7
Gu 2005	2005	SCC (surgery+chemotherapy)	50	China	Tissue	10%	Immunohistochemistry	7
Li 2005	2005	SCC	43	China	Tissue	10%	Immunohistochemistry	9
Fan 2006	2006	SCC	40	China	Tissue	10%	Immunohistochemistry	7
Liu 2006	2006	SCC	60	China	Tissue	25%	Immunohistochemistry	6
Han 2007	2007	SCC	40	Turkey	Tissue	10%	Immunohistochemistry	7
Ishida 2007	2007	SCC	32	Japan	Tissue	20%	Immunohistochemistry	8
Wang 2008	2008	SCC	48	China	Tissue	25%	Immunohistochemistry	8
Zhang 2008	2008	SCC	45	China	Tissue	NA	RT-PCR	7
Lin 2010	2010	SCC	148	China	Tissue	10%	Immunohistochemistry	8
Taghavi 2010	2010	SCC	80	Iran	Tissue	50%	Immunohistochemistry	8
Zhang 2010	2010	SCC	90	China	Tissue	NA	Immunohistochemistry	7
Arsenijevic 2012	2012	SCC	41	Serbia	Tissue	NA	Immunohistochemistry	6
Liu 2012	2012	SCC	189	China	Tissue	NA	Immunohistochemistry	6
Li 2013	2013	SCC	48	China	Tissue	NA	RT-PCR	7
Shiozaki 2013	2013	SCC	69	Japan	Tissue	30%	Immunohistochemistry	8
Zhang 2013	2013	SCC	51	China	Tissue	NA	Western blot	7
Zhang 2014	2014	SCC	62	China	Tissue	50%	Immunohistochemistry	7
Cheng 2015	2015	SCC	80	China	Tissue	25%	Immunohistochemistry	8
Lin 2016	2016	SCC	153	China	Tissue	10%	Immunohistochemistry	9