Neurogenomics of the Sympathetic Neurotransmitter Switch Indicates That Different Mechanisms Steer Cholinergic Differentiation in Rat and Chicken Models

Table 3

Results of the GO analysis including a statistical rating for the overrepresented Functional Annotation Clusters in both rat and chicken sets of genes.

	Chick			Rat
Category	Term	Fold Enrichment	Benjamini	Category	Term	Fold Enrichment	Benjamini
Annotation Cluster 1	Enrichment Score: 6.29			Annotation Cluster 6	Enrichment Score: 3.32
GOTERM_BP_FAT	GO:0007267~cell-cell signaling*	2.5	0.00014	GOTERM_BP_FAT	GO:0007267~cell-cell signaling*	2.0	0.00100
GOTERM_BP_FAT	GO:0019226~transmission of nerve impulse	2.6	0.00016	GOTERM_BP_FAT	GO:0019226~transmission of nerve impulse	1.8	0.04829
GOTERM_BP_FAT	GO:0050877~neurological system process	2.0	0.00013	GOTERM_BP_FAT	GO:0050877~neurological system process	1.4	0.09617
GOTERM_BP_FAT	GO:0007268~synaptic transmission	2.5	0.00171	GOTERM_BP_FAT	GO:0007268~synaptic transmission	1.7	0.15680
Annotation Cluster 2	Enrichment Score: 4.82			Annotation Cluster 4	Enrichment Score: 4.92
GOTERM_BP_FAT	GO:0048545~response to steroid hormone stimulus*	2.5	0.00013	GOTERM_BP_FAT	GO:0009719~response to endogenous stimulus*	1.7	0.00034
GOTERM_BP_FAT	GO:0032355~response to estradiol stimulus	4.1	0.00052	GOTERM_BP_FAT	GO:0010033~response to organic substance	1.5	0.00058
GOTERM_BP_FAT	GO:0009725~response to hormone stimulus	2.0	0.00093	GOTERM_BP_FAT	GO:0009725~response to hormone stimulus	1.7	0.00480
GOTERM_BP_FAT	GO:0010033~response to organic substance	1.7	0.00097	GOTERM_BP_FAT	GO:0048545~response to steroid hormone stimulus	1.8	0.01490
GOTERM_BP_FAT	GO:0043627~response to estrogen stimulus	3.0	0.00163
GOTERM_BP_FAT	GO:0009719~response to endogenous stimulus*	1.8	0.00283
GOTERM_BP_FAT	GO:0031960~response to corticosteroid stimulus	2.7	0.01533
GOTERM_BP_FAT	GO:0051384~response to glucocorticoid stimulus	2.7	0.02100
Annotation Cluster 5	Enrichment Score: 4.33			Annotation Cluster 3	Enrichment Score: 5.63
GOTERM_BP_FAT	GO:0022610~biological adhesion*	2.2	0.00052	GOTERM_BP_FAT	GO:0007155~cell adhesion*	2.0	0.00006
GOTERM_BP_FAT	GO:0007155~cell adhesion*	2.2	0.00052	GOTERM_BP_FAT	GO:0022610~biological adhesion*	2.0	0.00006
GOTERM_BP_FAT	GO:0016337~cell-cell adhesion	1.9	0.19556	GOTERM_BP_FAT	GO:0016337~cell-cell adhesion	2.0	0.04376
Annotation Cluster 7	Enrichment Score: 4.1			Annotation Cluster 2	Enrichment Score: 5.80
GOTERM_BP_FAT	GO:0030182~neuron differentiation*	2.1	0.00049	GOTERM_BP_FAT	GO:0030182~neuron differentiation*	2.1	0.00001
GOTERM_BP_FAT	GO:0048812~neuron projection morphogenesis	2.7	0.00119	GOTERM_BP_FAT	GO:0048666~neuron development	2.3	0.00002
GOTERM_BP_FAT	GO:0032989~cellular component morphogenesis	2.1	0.00162	GOTERM_BP_FAT	GO:0031175~neuron projection development	2.3	0.00008
GOTERM_BP_FAT	GO:0048858~cell projection morphogenesis	2.5	0.00173	GOTERM_BP_FAT	GO:0030030~cell projection organization	2.1	0.00006
GOTERM_BP_FAT	GO:0000904~cell morphogenesis involved in differentiation	2.5	0.00191	GOTERM_BP_FAT	GO:0048812~neuron projection morphogenesis	2.5	0.00014
GOTERM_BP_FAT	GO:0000902~cell morphogenesis	2.2	0.00193	GOTERM_BP_FAT	GO:0048858~cell projection morphogenesis	2.4	0.00018
GOTERM_BP_FAT	GO:0048666~neuron development	2.1	0.00303	GOTERM_BP_FAT	GO:0032990~cell part morphogenesis	2.3	0.00047
GOTERM_BP_FAT	GO:0032990~cell part morphogenesis	2.4	0.00297	GOTERM_BP_FAT	GO:0000902~cell morphogenesis	2.0	0.00060
GOTERM_BP_FAT	GO:0048667~cell morphogenesis involved in neuron differentiation	2.4	0.01158	GOTERM_BP_FAT	GO:0000904~cell morphogenesis involved in differentiation	2.2	0.00099
GOTERM_BP_FAT	GO:0031175~neuron projection development	2.1	0.01179	GOTERM_BP_FAT	GO:0007409~axonogenesis	2.4	0.00095
GOTERM_BP_FAT	GO:0006928~cell motion	1.9	0.01572	GOTERM_BP_FAT	GO:0032989~cellular component morphogenesis	1.9	0.00168
GOTERM_BP_FAT	GO:0030030~cell projection organization	1.9	0.01716	GOTERM_BP_FAT	GO:0048667~cell morphogenesis involved in neuron differentiation	2.2	0.00545
GOTERM_BP_FAT	GO:0007409~axonogenesis	2.3	0.03259	GOTERM_BP_FAT	GO:0007411~axon guidance	1.9	0.39703
GOTERM_BP_FAT	GO:0007411~axon guidance	2.3	0.25197
Annotation Cluster 8	Enrichment Score: 3.19			Annotation Cluster 8	Enrichment Score: 3.03
GOTERM_BP_FAT	GO:0006928~cell motion*	1.9	0.01572	GOTERM_BP_FAT	GO:0006928~cell motion*	1.75553	0.014535426
GOTERM_BP_FAT	GO:0016477~cell migration	2.1	0.02150	GOTERM_BP_FAT	GO:0016477~cell migration	1.8	0.04952
GOTERM_BP_FAT	GO:0051674~localization of cell	2.0	0.03139	GOTERM_BP_FAT	GO:0051674~localization of cell	1.7	0.09427
GOTERM_BP_FAT	GO:0048870~cell motility	2.0	0.03139	GOTERM_BP_FAT	GO:0048870~cell motility	1.7	0.09427
Annotation Cluster 11	Enrichment Score: 2.96			Annotation Cluster 1	Enrichment Score: 6.19
GOTERM_BP_FAT	GO:0001944~vasculature development*	2.2	0.01832	GOTERM_BP_FAT	GO:0001944~vasculature development*	2.5	0.00005
GOTERM_BP_FAT	GO:0048514~blood vessel morphogenesis	2.3	0.024790429	GOTERM_BP_FAT	GO:0001568~blood vessel development	2.5	0.00006
GOTERM_BP_FAT	GO:0001568~blood vessel development	2.1	0.026514792	GOTERM_BP_FAT	GO:0048514~blood vessel morphogenesis	2.6	0.00008
GOTERM_BP_FAT	GO:0001525~angiogenesis	2.3	0.118658169	GOTERM_BP_FAT	GO:0001525~angiogenesis	2.4	0.02003

*Identical GO categories overrepresented in the two groups of differentially expressed genes including synaptic transmission, neuron differentiation, neuron development, cell adhesion, and cell migration.