Desmosomal Molecules In and Out of Adhering Junctions: Normal and Diseased States of Epidermal, Cardiac and Mesenchymally Derived Cells
Table 1
Shown are specific cell-cell adhering junctions containing transmembrane glycoproteins and cytoplasmic plaque proteins of “classic” desmosomes and adherens junctions (AJs). Special types of adhering junctions containing desmosomal proteins in human tissues and cell cultures.
Type
Cells
Transmembrane glycoproteins
Some representative plaque proteins
References
Macula adhaerens (desmosome)
Epithelial and mesothelial cells and carcinomas derived therefrom, cardiomyocytes of immature hearts and cardiac conductive cells
Desmogleins-1-4 Desmocollins-1-3
Plakophilins-1-3 Plakoglobin Desmoplakin
Franke et al. [10, 11] Cowin et al. [12] Mertens et al. [13]
Area composita (composite junction)
Cardiomyocytes and Purkinje fiber cells
N-Cadherin Cadherin-11 Desmoglein-2 Desmocollin-2
- and -Catenin Proteins p120, p0071 and ARVCF Plakoglobin Plakophilin-2 Desmoplakin Afadin Myozap
Franke et al. [14] Pieperhoff and Franke [15] Goossens et al. [16] Seeger et al. [17]
Complexus adhaerens
Certain endothelia (spec. endothelial and virgultar tissues of lymph node sinus)
VE-Cadherin N-Cadherin Claudin-5 JAM-A
- and -Catenin Protein p120 Plakoglobin Desmoplakin, Afadin
Schmelz and Franke Hämmerling et al. [18] Moll et al. [19]
Zona limitans externa
Neural retina
N-Cadherin
Neurojungin - and -Catenin Plakoglobin Plakophilin-2
