Double-Blind, Placebo-Controlled, Randomized Study Comparing 0.0003% Calcitriol with 0.1% Tacrolimus Ointments for the Treatment of Endemic Pityriasis Alba

Table 2

Changes in repigmented area (%), colorimetric values (L*, a*), and TEWL (g/m²/h) on target lesions of PA. Data are shown initially, and at the end of study for calcitriol, tacrolimus and placebo.

	0.0003% Calcitriol (𝑛=19)			0.1% Tacrolimus (𝑛=18)			Placebo (𝑛=19)
	Onset	8 weeks	𝑃	Onset	8 weeks	𝑃	Onset	8 weeks	𝑃
Reduced area (%)	0	68.2 (24.7)	<0.001	0	69.1 (25.1)	<0.001	0	47.6 (28.9)	<0.001
L^∗Δ	4.2 (4.3)	2.3 (1.9)	0.01	4.1 (1.1)	1.8 (1.2)	0.001	4.3   (2.8)	2.7 (2.2)	0.09
a^∗Δ	−0.4 (1.4)	0.1 (2.1)	0.35	−0.5 (1.5)	−0.3 (1.1)	0.65	0.4   (1.1)	−0.2 (1.6)	0.09
TEWL Δ	4.8 (4.3)	1.6 (1.3)	0.008	4 (3.7)	1.7 (1)	0.01	4   (4.1)	3.5 (3)	0.63

Δ=lesional−perilesional values.
Data are expressed as mean, standard deviation in parenthesis.