Differential Downregulation of E-Cadherin and Desmoglein by Epidermal Growth Factor

Figure 1

Cadherin staining 48 h postincisional wounding in vivo. Left Panel: E-cadherin immunoreactivity at wound margin 48 h after introduction of an incisional wound. Bar=150 μm. Inset: Higher magnification of the advancing edge of epithelium. Note that E-cadherin immunoreactivity is present in all but a few cells at the very tip of the migrating epithelium. Bar=50 μm. Right Panel: Desmoglein immunoreactivity at wound margin 48 h after introduction of an incisional wound. Bar=150 μm. Inset: Higher magnification of the advancing edge of epithelium. Note that desmoglein immunoreactivity is largely absent from the tip of the migrating epithelium. Bar=50 μm.