Research Article

Differential Downregulation of E-Cadherin and Desmoglein by Epidermal Growth Factor

Figure 6

Desmoglein-2 does not internalize with E-cadherin. SCC 12F cells were treated with EGF for the indicated times, fixed, then probed with E-cadherin or desmoglein-2 antibodies. The desmosomal cadherin desmoglein-2 is relocalized from the cell borders at 6–8 hrs after EGF treatment. Note punctate cytoplasmic staining (white arrows). This pattern differs from that observed for the adherens junctional cadherin, E-cadherin, where strong border staining is evident at 6 hours post EGF treatment.
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