Double-Blinded, Vehicle-Controlled Proof of Concept Study to Investigate the Recurrence of Inflammatory and Noninflammatory Acne Lesions Using Tretinoin Gel (Microsphere) 0.04% in Male Patients after Oral Isotretinoin Use

Table 4

Local tolerability assessments.

Evaluator-assessed erythema, dryness, and peeling
Grade	Severity	Erythema	Dryness	Peeling
0	Absent	No redness	None	No peeling
1	Slight	Faint red or pink coloration, barely perceptible	Barely perceptible dryness with no flakes or fissure formation	Mild localized peeling
2	Mild	Light red or pink coloration	Easily perceptible dryness with no flakes or fissure formation	Mild and diffuse peeling
3	Moderate	Medium red coloration	Easily noted dryness and flakes but no fissure formation	Moderate and diffuse peeling
4	Severe	Beet red coloration	Easily noted dryness with flakes and fissure formation	Moderate to prominent, dense peeling