In Vivo Noninvasive Imaging of Healthy Lower Lip Mucosa: A Correlation Study between High-Definition Optical Coherence Tomography, Reflectance Confocal Microscopy, and Histology

Table 4

Cellular features in lower lip mucosa evaluated in vivo by reflectance confocal microscopy and high-definition optical coherence tomography.

Reference mark (𝜇m)	Cellular structure	RCM image from Vivastack sets (𝜇m)	HD-OCT image from “slice” mode (𝜇m)
Z0	Nuclei (where visible)	10–13.2	NA
Z1	Nuclei	12–14.3	9.7–13.5
Z2	Nuclei	11–16.8	12–17.6
Z3	Nuclei	10–14	10.9–16.9
Z4	Nuclei	NA	NA
Z5	Nuclei	NA	NA
Z6	Nuclei	NA	NA
Z0	Cytoplasmic border	21–34.2	24.6–29.4
Z1	Cytoplasmic border	22–27	21–22.9
Z2	Cytoplasmic border	23–35.4	22.4–35
Z3	Cytoplasmic border	25–34	21.9–33.8
Z4	Cytoplasm	21–32	18.8–20.2
Z5	Cytoplasm	16–22	NA
Z6	Cytoplasm	NA	NA
Z5-Z6	Junctional epithelium	16–32	20.5–29

NA: not applicable.