About this Journal Submit a Manuscript Table of Contents
Dermatology Research and Practice
Volume 2013 (2013), Article ID 389031, 6 pages
Research Article

Psoriasis and Cardiovascular Risk: Assessment by CUORE Project Risk Score in Italian Patients

Department of Dermatology, University of Palermo, Via del Vespro 131, 90123 Palermo, Italy

Received 23 July 2013; Accepted 7 August 2013

Academic Editor: Ruben Queiro-Silva

Copyright © 2013 Spyridoula Doukaki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Psoriasis is a common inflammatory and immune-mediated skin disease. There is growing controversy as to whether cardiovascular risk is elevated in psoriasis. A number of studies suggest a high prevalence of cardiovascular risk factors as well as cardiovascular diseases in psoriasis patients. Objective. The objective of this study was to estimate cardiovascular risk score in psoriasis patients and the relation between cardiovascular risk and psoriasis features. Cardiovascular risk was assessed by CUORE project risk score built within the longitudinal study of the Italian CUORE project and suited to populations with a low rate of coronary heart disease. Results. A case-control study in 210 psoriasis outpatients and 111 controls with skin diseases other than psoriasis was performed. CUORE project risk score was higher in patients than controls ( versus , ). Compared to controls, psoriasis patients have higher risk of developing major cardiovascular events. Cardiovascular risk was not related to psoriasis characteristics. Conclusion. Increased focus on identifying cardiovascular risk factors and initiation of preventive lifestyle changes or therapeutic interventions in patients with psoriasis is warranted.