About this Journal Submit a Manuscript Table of Contents
Dermatology Research and Practice
Volume 2013 (2013), Article ID 651737, 8 pages
http://dx.doi.org/10.1155/2013/651737
Review Article

Chronic Urticaria: Indian Context—Challenges and Treatment Options

1Consultant Allergist & Immunologist, Department of Allergy & Immunology, Apollo Gleneagles Hospital, 58 Canal Circular Road, Kolkata, West Bengal 700 054, India
2Department of Paediatric Pulmonology, Vision Care Hospital, Mukundapur, Kolkata West Bengal 700099, India
3Department of Allergy, Immunology and Arthritis, Apollo Hospitals International Ltd., Bhat GIDC, Gandhinagar, Ahmedabad, Gujarat 382428, India
4Dr. Niphadkar’s Asthma and Allergy Health Clinic, Hindu Colony Lane No. 1, Dadar (East), Mumbai 400 014, India
5Department of Pulmonary Medicine, JSS Medical College, JSS University, Mysore, Karnataka 570 004, India
6Department of Medicine, Indraprastha Apollo Hospital, Mathura Road, Jasola Vihar, New Delhi 110076, India
7Clinical Marketing Manager, Phadia/IDD, Thermo Fisher Scientific, Units No. 7, 10 & 11, Splendor Forum, Plot No. 3, Disttrict Centre, Jasola, New Delhi 110025, India

Received 11 July 2013; Accepted 20 August 2013

Academic Editor: Tadamichi Shimizu

Copyright © 2013 Sujoy Khan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Zuberbier, R. Asero, C. Bindslev-Jensen et al., “EAACI/GA2LEN/EDF/WAO guideline: definition, classification and diagnosis of urticaria,” Allergy, vol. 64, no. 10, pp. 1417–1426, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. T. Zuberbier, R. Asero, C. Bindslev-Jensen, et al., “EAACI/GA2LEN/EDF/WAO guideline: management of urticaria,” Allergy, vol. 64, pp. 1427–1443, 2009. View at Publisher · View at Google Scholar
  3. M. Maurer, K. Weller, C. Bindslev-Jensen et al., “Unmet clinical needs in chronic spontaneous urticaria. A GA2LEN task force report,” Allergy, vol. 66, no. 3, pp. 317–330, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Fromer, “Treatment options for the relief of chronic idiopathic urticaria symptoms,” Southern Medical Journal, vol. 101, no. 2, pp. 186–192, 2008. View at Scopus
  5. K. Godse, V. Zawar, D. Krupashankar et al., “Consensus statement on the management of urticaria,” Indian Journal of Dermatology, vol. 56, no. 5, pp. 485–489, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. G. N. Konstantinou, R. Asero, M. Ferrer et al., “EAACI taskforce position paper: evidence for autoimmune urticaria and proposal for defining diagnostic criteria,” Allergy, vol. 68, pp. 27–36, 2013.
  7. S. Pastore, I. Berti, and G. Longo, “Autoimmune chronic urticaria: transferability of autologous serum skin test,” European Journal of Pediatrics, vol. 172, p. 569, 2013. View at Publisher · View at Google Scholar
  8. L. Brunetti, R. Francavilla, V. L. Miniello et al., “High prevalence of autoimmune urticaria in children with chronic urticaria,” Journal of Allergy and Clinical Immunology, vol. 114, no. 4, pp. 922–927, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. K. S. Wan and C. S. Wu, “The essential role of anti-thyroid antibodies in chronic idiopathic urticaria,” Endocrine Research, vol. 38, pp. 85–88, 2013. View at Publisher · View at Google Scholar
  10. T. Takeda, Y. Sakurai, S. Takahagi et al., “Increase of coagulation potential in chronic spontaneous urticaria,” Allergy, vol. 66, no. 3, pp. 428–433, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. Z. Huilan, L. Runxiang, L. Bihua, and G. Qing, “Role of the subgroups of T, B, natural killer lymphocyte and serum levels of interleukin-15, interleukin-21 and immunoglobulin e in the pathogenesis of urticaria,” Journal of Dermatology, vol. 37, no. 5, pp. 441–447, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. U. Raap, D. Wieczorek, M. Gehring et al., “Increased levels of serum IL-31 in chronic spontaneous urticaria,” Experimental Dermatology, vol. 19, no. 5, pp. 464–466, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Lopes, D. Machado, S. Pedreiro, et al., “Different frequencies of tc17/tc1 and th17/th1 cells in chronic spontaneous urticaria,” International Archives of Allergy and Immunology, vol. 161, pp. 155–162, 2013.
  14. J. C. dos Santos, M. H. Azor, V. Y. Nojima et al., “Increased circulating pro-inflammatory cytokines and imbalanced regulatory T-cell cytokines production in chronic idiopathic urticaria,” International Immunopharmacology, vol. 8, no. 10, pp. 1433–1440, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. W.-C. Chen, B.-L. Chiang, H. E. Liu, S.-J. Leu, and Y.-L. Lee, “Defective functions of circulating CD4+CD25+ and CD4+CD25 T cells in patients with chronic ordinary urticaria,” Journal of Dermatological Science, vol. 51, no. 2, pp. 121–130, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. F. D. Lourenço, M. H. Azor, J. C. Santos et al., “Activated status of basophils in chronic urticaria leads to interleukin-3 hyper-responsiveness and enhancement of histamine release induced by anti-IgE stimulus,” British Journal of Dermatology, vol. 158, no. 5, pp. 979–986, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Caproni, B. Giomi, L. Melani et al., “Cellular infiltrate and related cytokines, chemokines, chemokine receptors and adhesion molecules in chronic autoimmune urticaria: comparison between spontaneous and autologous serum skin test induced wheal,” International Journal of Immunopathology and Pharmacology, vol. 19, no. 3, pp. 507–515, 2006. View at Scopus
  18. A. Puccetti, C. Bason, S. Simeoni et al., “In chronic idiopathic urticaria autoantibodies against FcεRII/CD23 induce histamine release via eosinophil activation,” Clinical and Experimental Allergy, vol. 35, no. 12, pp. 1599–1607, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Kasperska-Zajac, Z. Brzoza, and B. Rogala, “Increased concentration of platelet-derived chemokinesin serum of patients with delayed pressure urticaria,” European Cytokine Network, vol. 19, no. 2, pp. 89–91, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Caproni, B. Giomi, W. Volpi et al., “Chronic idiopathic urticaria: infiltrating cells and related cytokines in autologous serum-induced wheals,” Clinical Immunology, vol. 114, no. 3, pp. 284–292, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Caproni, C. Cardinali, B. Giomi et al., “Serological detection of eotaxin, IL-4, IL-13, IFN-γ, MIP-1α, TARC and IP-10 in chronic autoimmune urticaria and chronic idiopathic urticaria,” Journal of Dermatological Science, vol. 36, no. 1, pp. 57–59, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. J. C. Santos, C. A. de Brito, E. A. Futata et al., “Up-regulation of chemokine C-C ligand 2 (CCL2) and C-X-C chemokine 8 (CXCL8) expression by monocytes in chronic idiopathic urticaria,” Clinical and Experimental Immunology, vol. 167, no. 1, pp. 129–136, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Bossi, B. Frossi, O. Radillo et al., “Mast cells are critically involved in serum-mediated vascular leakage in chronic urticaria beyond high-affinity IgE receptor stimulation,” Allergy, vol. 66, no. 12, pp. 1538–1545, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Ferrer, J. M. Nuñez-Córdoba, E. Luquin et al., “Serum total tryptase levels are increased in patients with active chronic urticaria,” Clinical and Experimental Allergy, vol. 40, no. 12, pp. 1760–1766, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. J.-I. Kashiwakura, T. Ando, K. Matsumoto et al., “Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy,” Journal of Clinical Investigation, vol. 122, no. 1, pp. 218–228, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. R. Asero, M. Lorini, S. U. Chong, T. Zuberbier, and A. Tedeschi, “Assessment of histamine-releasing activity of sera from patients with chronic urticaria showing positive autologous skin test on human basophils and mast cells,” Clinical & Experimental Allergy, vol. 34, pp. 1111–1114, 2004.
  27. K.-L. Chang, Y.-H. Yang, H.-H. Yu, J.-H. Lee, L.-C. Wang, and B.-L. Chiang, “Analysis of serum total IgE, specific IgE and eosinophils in children with acute and chronic urticaria,” Journal of Microbiology, Immunology and Infection, vol. 46, no. 1, pp. 53–58, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. T. Zuberbier, “The role of allergens and pseudoallergens in urticaria,” Journal of Investigative Dermatology Symposium Proceedings, vol. 6, no. 2, pp. 132–134, 2001. View at Scopus
  29. K. Kulthanan and C. Wachirakahan, “Prevalence and clinical characteristics of chronic urticaria and positive skin prick testing to mites,” Acta Dermato-Venereologica, vol. 88, no. 6, pp. 584–588, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. P. A. Mahesh, P. A. Kushalappa, A. D. Holla, and P. K. Vedanthan, “House dust mite sensitivity is a factor in chronic urticaria,” Indian Journal of Dermatology, Venereology and Leprology, vol. 71, no. 2, pp. 99–101, 2005. View at Scopus
  31. Z. Caliskaner, S. Ozturk, M. Turan, and M. Karaayvaz, “Skin test positivity to aeroallergens in the patients with chronic urticaria without allergic respiratory disease,” Journal of Investigational Allergology and Clinical Immunology, vol. 14, no. 1, pp. 50–54, 2004. View at Scopus
  32. A. F. Finn Jr., A. P. Kaplan, R. Fretwell, R. Qu, and J. Long, “A double-blind, placebo-controlled trial of fexofenadine HCl in the treatment of chronic idiopathic urticaria,” Journal of Allergy and Clinical Immunology, vol. 104, no. 5, pp. 1071–1078, 1999. View at Publisher · View at Google Scholar · View at Scopus
  33. H. S. Nelson, R. Reynolds, and J. Mason, “Fexofenadine HCl is safe and effective for treatment of chronic idiopathic urticaria,” Annals of Allergy, Asthma and Immunology, vol. 84, no. 5, pp. 517–522, 2000. View at Scopus
  34. C. Weber-Schoendorfer and C. Schaefer, “The safety of cetirizine during pregnancy. A prospective observational cohort study,” Reproductive Toxicology, vol. 26, no. 1, pp. 19–23, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. M. S. Blaiss and ACAAI-ACOG(American College of Allergy, Asthma, and Immunology and American College of Obstetricians and Gynecologists), “Management of rhinitis and asthma in pregnancy,” Annals of Allergy, Asthma and Immunology, vol. 90, pp. 16–22, 2003. View at Scopus
  36. D. R. Weldon, “Quality of life in patients with urticaria,” Allergy and Asthma Proceedings, vol. 27, no. 2, pp. 96–99, 2006. View at Scopus
  37. E. Poon, P. T. Seed, M. W. Greaves, and A. Kobza-Black, “The extent and nature of disability in different urticarial conditions,” British Journal of Dermatology, vol. 140, no. 4, pp. 667–671, 1999. View at Publisher · View at Google Scholar · View at Scopus
  38. J.-J. Grob and C. Gaudy-Marqueste, “Urticaria and quality of life,” Clinical Reviews in Allergy and Immunology, vol. 30, no. 1, pp. 47–51, 2006. View at Scopus
  39. P. Staubach, A. Eckhardt-Henn, M. Dechene et al., “Quality of life in patients with chronic urticaria is differentially impaired and determined by psychiatric comorbidity,” British Journal of Dermatology, vol. 154, no. 2, pp. 294–298, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. Y. M. Ye, J. W. Park, S. H. Kim, et al., “Clinical evaluation of the computerized chronic urticaria-specific quality of life questionnaire in Korean patients with chronic urticaria,” Clinical and Experimental Dermatology, vol. 37, pp. 722–728, 2012.
  41. A. Młynek, M. Magerl, M. Hanna et al., “The German version of the chronic urticaria quality-of-life questionnaire: factor analysis, validation, and initial clinical findings,” Allergy, vol. 64, no. 6, pp. 927–936, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. P. Staubach, M. Dechene, M. Metz et al., “High prevalence of mental disorders and emotional distress in patients with chronic spontaneous urticaria,” Acta Dermato-Venereologica, vol. 91, no. 5, pp. 557–561, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Fukuda, T. Shimoyama, N. Umegaki, T. Mikami, H. Nakano, and A. Munakata, “Effect of Helicobacter pylori eradication in the treatment of Japanese patients with chronic idiopathic urticaria,” Journal of Gastroenterology, vol. 39, no. 9, pp. 827–830, 2004. View at Publisher · View at Google Scholar · View at Scopus
  44. M. K. Yadav, J. P. Rishi, and S. Nijawan, “Chronic urticaria and Helicobacter pylori,” Indian Journal of Medical Sciences, vol. 62, no. 4, pp. 157–162, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. E. Magen, J. Mishal, M. Schlesinger, and S. Scharf, “Eradication of Helicobacter pylori infection equally improves chronic urticaria with positive and negative autologous serum skin test,” Helicobacter, vol. 12, no. 5, pp. 567–571, 2007. View at Publisher · View at Google Scholar · View at Scopus
  46. A. Campanati, R. Gesuita, M. Giannoni, et al., “Role of small intestinal bacterial overgrowth and Helicobacter pylori infection in chronic spontaneous urticaria: a prospective analysis,” Acta Dermato-Venereologica, vol. 93, pp. 161–164, 2013. View at Publisher · View at Google Scholar
  47. G. W. Scadding and G. K. Scadding, “Recent advances in antileukotriene therapy,” Current Opinion in Allergy and Clinical Immunology, vol. 10, no. 4, pp. 370–376, 2010. View at Publisher · View at Google Scholar · View at Scopus
  48. B. J. Lipworth, “Leukotriene-receptor antagonists,” The Lancet, vol. 353, no. 9146, pp. 57–62, 1999. View at Publisher · View at Google Scholar · View at Scopus
  49. G. E. Rovati and V. Capra, “Cysteinyl-leukotriene receptors and cellular signals,” The Scientific World Journal, vol. 7, pp. 1375–1392, 2007. View at Publisher · View at Google Scholar · View at Scopus
  50. Z. Erbagci, “The leukotriene receptor antagonist montelukast in the treatment of chronic idiopathic urticaria: a single-blind, placebo-controlled, crossover clinical study,” Journal of Allergy and Clinical Immunology, vol. 110, no. 3, pp. 484–488, 2002. View at Publisher · View at Google Scholar · View at Scopus
  51. M. Kosnik and T. Subic, “Add-on montelukast in antihistamine-resistant chronic idiopathic urticaria,” Respiratory Medicine, vol. 105, no. 1, pp. S84–S88, 2011. View at Publisher · View at Google Scholar · View at Scopus
  52. K.-S. Wan, “Efficacy of leukotriene receptor antagonist with an anti-H1 receptor antagonist for treatment of chronic idiopathic urticaria,” Journal of Dermatological Treatment, vol. 20, no. 4, pp. 194–197, 2009. View at Publisher · View at Google Scholar · View at Scopus
  53. G. di Lorenzo, A. D'Alcamo, M. Rizzo et al., “Leukotriene receptor antagonists in monotherapy or in combination with antihistamines in the treatment of chronic urticaria: a systematic review,” Journal of Asthma and Allergy, no. 2, pp. 9–16, 2009. View at Scopus
  54. S. Khan and N. Lynch, “Efficacy of montelukast as added therapy in patients with chronic idiopathic urticaria,” Inflammation and Allergy, vol. 11, no. 3, pp. 235–243, 2012. View at Scopus
  55. E. di Leo, E. Nettis, A. M. Aloia et al., “Cyclosporin-A efficacy in chronic idiopathic urticaria,” International Journal of Immunopathology and Pharmacology, vol. 24, no. 1, pp. 195–200, 2011. View at Scopus
  56. C. Boubouka, C. Charissi, D. Kouimintzis, D. Kalogeromitros, P. Stavropoulos, and A. Katsarou, “Treatment of autoimmune urticaria with low-dose cyclosporin a: a one-year follow-up,” Acta Dermato-Venereologica, vol. 91, no. 1, pp. 50–54, 2011. View at Publisher · View at Google Scholar · View at Scopus
  57. A. Kessel and E. Toubi, “Cyclosporine-A in severe chronic urticaria: the option for long-term therapy,” Allergy, vol. 65, no. 11, pp. 1478–1482, 2010. View at Publisher · View at Google Scholar · View at Scopus
  58. H. Serhat Inaloz, S. Ozturk, C. Akcali, N. Kirtak, and M. Tarakcioglu, “Low-dose and short-term cyclosporine treatment in patients with chronic idiopathic urticaria: a clinical and immunological evaluation,” Journal of Dermatology, vol. 35, no. 5, pp. 276–282, 2008. View at Publisher · View at Google Scholar · View at Scopus
  59. K. V. Godse, “Cyclosporine in chronic idiopathic urticaria with positive autologous serum skin test,” Indian Journal of Dermatology, vol. 53, no. 2, pp. 101–102, 2008. View at Publisher · View at Google Scholar · View at Scopus
  60. S. M. Hollander, S. S. Joo, and H. J. Wedner, “Factors that predict the success of cyclosporine treatment for chronic urticaria,” Annals of Allergy, Asthma and Immunology, vol. 107, no. 6, pp. 523–528, 2011. View at Publisher · View at Google Scholar · View at Scopus
  61. S. Darras, M. Ségard, L. Mortier, A. Bonnevalle, and P. Thomas, “Treatment of solar urticaria by intravenous immunoglobulins and PUVAtherapy,” Annales de Dermatologie et de Venereologie, vol. 131, no. 1, pp. 65–69, 2004. View at Scopus
  62. K. Aydogan, S. K. Karadogan, S. Tunali, and H. Saricaoglu, “Narrowband ultraviolet B (311nm, TL01) phototherapy in chronic ordinary urticaria,” International Journal of Dermatology, vol. 51, no. 1, pp. 98–103, 2012. View at Publisher · View at Google Scholar · View at Scopus
  63. B. Engin, M. Özdemir, A. Balevi, and I. Mevlitoǧlu, “Treatment of chronic urticaria with narrowband ultraviolet B phototherapy: a randomized controlled trial,” Acta Dermato-Venereologica, vol. 88, no. 3, pp. 247–251, 2008. View at Publisher · View at Google Scholar · View at Scopus
  64. G. Monfrecola, A. de Paulis, E. Prizio et al., “In vitro effects of ultraviolet A on histamine release from human basophils,” Journal of the European Academy of Dermatology and Venereology, vol. 17, no. 6, pp. 646–651, 2003. View at Publisher · View at Google Scholar · View at Scopus
  65. A. C. Lefévre, M. Deleuran, and C. A. Vestergaard, “A long term case series study of the effect of omalizumab on chronic spontaneous urticaria,” Annals of Dermatology, vol. 25, pp. 242–245, 2013. View at Publisher · View at Google Scholar
  66. M. Maurer, K. Rosén, H. J. Hsieh, et al., “Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria.,” The New England Journal of Medicine, vol. 368, pp. 924–935, 2013. View at Publisher · View at Google Scholar
  67. C. H. Song, S. Stern, M. Giruparajah, N. Berlin, and G. L. Sussman, “Long-term efficacy of fixed-dose omalizumab for patients with severe chronic spontaneous urticaria,” Annals of Allergy, Asthma & Immunology, vol. 110, pp. 113–117, 2013. View at Publisher · View at Google Scholar
  68. L. S. Cox, “How safe are the biologicals in treating asthma and rhinitis?” Allergy, Asthma and Clinical Immunology, vol. 5, no. 4, article 4, 2009. View at Publisher · View at Google Scholar · View at Scopus
  69. P. J. Cooper, G. Ayre, C. Martin, J. A. Rizzo, E. V. Ponte, and A. A. Cruz, “Geohelminth infections: a review of the role of IgE and assessment of potential risks of anti-IgE treatment,” Allergy, vol. 63, no. 4, pp. 409–417, 2008. View at Publisher · View at Google Scholar · View at Scopus
  70. S. K. Chow, “Management of chronic urticaria in Asia: 2010 AADV consensus guidelines,” Asia Pacific Allergy, vol. 2, pp. 149–160, 2012. View at Publisher · View at Google Scholar