Review Article
Pathogenesis of Chronic Urticaria: An Overview
Table 1
Infiltrating cells: pattern in urticarial wheal, uninvolved skin, and normal healthy control subjects [
4].
| Cell type | Urticarial wheal | Uninvolved skin | Healthy control subjects |
| Mast cells | Normal count | Normal count | Normal count | Lymphocytes | Raised T-lymphocyte count | More numerous T-lymphocytes than in lesional skin | Low T-lymphocyte counts | Neutrophils | Major cellular infiltrate at 60 minutes of evolution of urticarial wheal | Significantly less infiltration than in lesional skin | Insignificant | Eosinophils | Significantly higher number | Insignificant | Insignificant | Basophil | Significant number, especially at 30 minutes of evolution, of urticarial wheal | Less but relevant number | Insignificant |
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