Pathogenesis of Chronic Urticaria: An Overview

Table 1

Infiltrating cells: pattern in urticarial wheal, uninvolved skin, and normal healthy control subjects [4].

Cell type	Urticarial wheal	Uninvolved skin	Healthy control subjects
Mast cells	Normal count	Normal count	Normal count
Lymphocytes	Raised T-lymphocyte count	More numerous T-lymphocytes than in lesional skin	Low T-lymphocyte counts
Neutrophils	Major cellular infiltrate at 60 minutes of evolution of urticarial wheal	Significantly less infiltration than in lesional skin	Insignificant
Eosinophils	Significantly higher number	Insignificant	Insignificant
Basophil	Significant number, especially at 30 minutes of evolution, of urticarial wheal	Less but relevant number	Insignificant