Clinical and Genetic Review of Hereditary Acral Reticulate Pigmentary Disorders

Table 1

Characteristic clinical features of hereditary reticulate pigmentary disorders.

Disorders	Primary skin lesion	Additional features
DSH	Mixed reticular hyper- and hypopigmentation on distal extremities	Freckle-like macules on the face Palms and soles are spared
DUH	Mixed reticular hyper- and hypopigmentation on trunk and distal extremities (generalized)	Freckle-like macules on the face Palms and soles are rarely involved
RAPK	Reticular hyperpigmented macules in distal extremities	Palmoplantar pits
DPR	Reticular hyperpigmentation of distal extremities and trunk (generalized)	Nonscarring alopecia and onychodystrophy
NFJS	Reticular hyperpigmentation of distal extremities and trunk (generalized) that fades after puberty	Palmoplantar keratoderma; Hypohydrosis; Absence of dermatoglyphics
EBS-MP	Blisters followed by hyper- and hypopigmented macules in reticular pattern with generalized or localized (extremities) distribution	Palmoplantar hyperkeratosis and nail dystrophy
ACD	Reticular hyper- and hypopigmented macules with generalized distribution	—

DSH: dyschromatosis symmetrica hereditaria; DUH: dyschromatosis universalis hereditaria; RAPK: reticulate acropigmentation of Kitamura; DPR: dermatopathia pigmentosa reticularis; NFJS: Naegeli-Franceschetti-Jadassohn Syndrome; EBS-MP: epidermolysis bullosa simplex with mottled pigmentation; ACD: amyloidosis cutis dyschromica.