Clinical and Genetic Review of Hereditary Acral Reticulate Pigmentary Disorders

Table 4

Histopathological features, electron microscopy.

Disorder	Electron Microscopy
DSH	Hyperpigmented macules⁢; (i) Many melanosomes in keratinocytes and few in melanocytes; Hypopigmented macules⁢; (i) Small immature melanosomes in the melanocytes with apoptotic changes
DUH	Hyperpigmented macules⁢; (i) Melanosome complexes
RAPK	Hyperpigmented macules⁢; (i) Increased number of melanocytes in the basal layer; (ii) Increased melanosomes in keratinocyte cytoplasm
DPR	Hyperpigmented macules⁢; (i) Increased number and size of melanosomes in the basal keratinocytes
NFJS	(i) Colloid-amyloid bodies in the papillary dermis and around sweat glands in the reticular dermis
EBS-MP	Hyperpigmented macules⁢; (i) Many melanosomes within the basal keratinocytes; (ii) Disorganization of keratin filaments; (iii) Keratinocyte vacuolization
ACD	(i) Amyloid fibrils

DSH: dyschromatosis symmetrica hereditaria; DUH: dyschromatosis universalis hereditaria; RAPK: reticulate acropigmentation of Kitamura;DPR: dermatopathia pigmentosa reticularis; NFJS: Naegeli-Franceschetti-Jadassohn Syndrome; EBS-MP: epidermolysis bullosa simplex with mottled pigmentation; ACD: amyloidosis cutis dyschromica.