Clinical and Genetic Review of Hereditary Acral Reticulate Pigmentary Disorders
Table 4
Histopathological features, electron microscopy.
Disorder
Electron Microscopy
DSH
Hyperpigmented macules (i) Many melanosomes in keratinocytes and few in melanocytes Hypopigmented macules (i) Small immature melanosomes in the melanocytes with apoptotic changes
DUH
Hyperpigmented macules (i) Melanosome complexes
RAPK
Hyperpigmented macules (i) Increased number of melanocytes in the basal layer (ii) Increased melanosomes in keratinocyte cytoplasm
DPR
Hyperpigmented macules (i) Increased number and size of melanosomes in the basal keratinocytes
NFJS
(i) Colloid-amyloid bodies in the papillary dermis and around sweat glands in the reticular dermis
EBS-MP
Hyperpigmented macules (i) Many melanosomes within the basal keratinocytes (ii) Disorganization of keratin filaments (iii) Keratinocyte vacuolization