Efficacy and Safety of the Traditional Japanese Medicine Keigairengyoto in the Treatment of Acne Vulgaris

Figure 3

Effect of Keigairengyoto in a stratified analysis focusing on patients with disease duration of 2.6 years or more. Patients were randomized into a conventional treatment group (control group, white circle) and a group with conventional treatment and Keigairengyoto (KRT group, filled circle), and they were treated for 12 weeks. The median acne duration for all patients in this study was 2.6 years. The total sum of noninflammatory and inflammatory acne in patients with an acne duration of 2.6 years or more was examined. Although there was a difference in the number of patients among the groups, the KRT group showed significantly greater reduction in the amount of acne at week 12. For the change in inflammatory skin rash in patients with an acne duration of 2.6 years or more, the amount of inflammatory acne at 2, 4, and 8 weeks was lower in the KRT group compared with the control group, with a significant difference at 2 and 8 weeks. Data are shown as the mean ± standard error. The number of patients at each evaluation time point for the control and KRT groups is as follows: pretreatment: control 15 and KRT 9; week 2: 14 and 9; week 4: 9 and 9; week 8: 10 and 7; and week 12: 8 and 4. P<0.05, Wilcoxon rank-sum test.