Efficacy of Chronic Antidepressant Treatments in a New Model of Extreme Anxiety in Rats

Table 1

Effects of subchronic fluoxetine (FLX) treatment (5 mg/kg/21 d, IP, 𝑛=9, median with limits of interquartile range values). Mann-Whitney U test: *𝑃<0.05; **𝑃<0.01(FLX versus Vehicle). Wilcoxon-test: ^#𝑃<0.05 (test versus baseline). Data were expressed as median with limits of interquartile range values.

Measures	Baseline (before treatment)		Test (after treatment)
	Vehicle (𝑛=9)	FLX (𝑛=9)	Vehicle (𝑛=9)	FLX (𝑛=9)
Number of jumps	23 (9.8–37.3)	21 (16.5–31.5)	22 (10.5–27)	9^*# (0–12.8)
Latency before the first jump (s)	15 (11.3–21.5)	14 (11.8–23.3)	16 (12.3–18)	27^*# (16.3–90)
Immobility (s)	140 (126.8–144.8)	59 (33.3–93.8)	164^# (140–176.8)	70** (58.8–115)