Table 1: Summary of recent studies examining the efficacy of antidepressants in the treatment of acute bipolar depression.

Positive studiesNegative studies
StudyNo. of participantsDrugCommentsStudyNo. of participantsDrugComments

Antidepressants as monotherapy
Amsterdam and Shults 2005 [13]34 ( , )Fluoxetine, olanzapine/fluoxetine combinationNo placebo controlMcElroy et al. 2010 (EMBOLDEN II) [14]740 ( , )Paroxetine
Parker et al. 2006 [16]10 BPIIEscitalopramSmall sample size
Agosti and Stewart 2007 [21]70 BP IIImipramine, phenelzineNo significance demonstrated
Amsterdam and Shults 2008 [17]83 BPIIVenlafaxineNo placebo control
Amsterdam and Shults 2010 [15]148 BPIIFluoxetineNo placebo control

Antidepressants with mood stabilizers
Schaffer et al. 2006 [27]20CitalopramSmall sample size, no placebo controlSachs et al. 2007 [29]366 ( , )Paroxetine, bupropion
Fonseca et al. 2006 [28]20EscitalopramSmall sample size, no placebo controlSidor et al. 2011 [32]1,034 (Meta- Analysis)Fluoxetine, paroxetine, bupropion, imipramine
Tamayo et al. 2009 [46]114Olanzapine/fluoxetine combinationConducted by Lilly Research Laboratories
Pilhatsch et al. 2010 [41]40Paroxetine, amitriptylineNo placebo control
Perlis et al. 2010 [45]410Olanzapine/fluoxetine combinationConducted by Lilly Research Laboratories