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Figure 3: Potential antidepressant molecular targets based on the predominant PI3K/AKT/GSK3 pathways. Note that some critical events have been omitted for clarity. SSRI: selective serotonin reuptake inhibitors; MAOi: monoamine oxidase inhibitors; BDNF: brain-derived neurotrophic factor; 5-HT: 5-hydroxytryptamine, serotonin.